Long-Term Intervention in Chronic Obstructive Pulmonary Disease, Vol. 191 Book

	Introduction
1	Definition of chronic obstructive pulmonary disease	1
2	COPD : worldwide prevalence	15
3	Worldwide mortality from COPD	37
4	Risk factors for the development of COPD	53
5	Risk factors for the progression of COPD	71
6	Socioeconomic burden of COPD	101
7	Pathology of COPD	119
8	Inflammatory mechanisms	139
9	Defective repair in COPD : the American hypothesis	165
10	Proteinases in COPD	201
11	Oxidative stress and COPD	223
12	Pathogenesis of infections in COPD patients	271
13	Extrapulmonary effects of COPD	295
14	Smoking cessation	315
15	Anticholinergics	353
16	Long-acting beta-adrenoreceptor agonists for the treatment of COPD	383
17	The role of glucocorticosteroids in the management of COPD	407
18	Antibiotics in COPD	423
19	Long-term intervention studies : [alpha]1-antitrypsin substitution	445
20	Surgery and transplantation for COPD	463
21	New therapies for COPD	479