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Immunosuppressant Analogs in Neuroprotection Book

Immunosuppressant Analogs in Neuroprotection
Immunosuppressant Analogs in Neuroprotection, An authoritative survey of the most recent scientific evidence showing how cyclosporin, FK-506, and their analogs-the neuroimmunophilins-evolved from being purely immunosuppressant drugs to neuroprotective agents. The book focuses on recent preclinica, Immunosuppressant Analogs in Neuroprotection has a rating of 3.5 stars
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Immunosuppressant Analogs in Neuroprotection, An authoritative survey of the most recent scientific evidence showing how cyclosporin, FK-506, and their analogs-the neuroimmunophilins-evolved from being purely immunosuppressant drugs to neuroprotective agents. The book focuses on recent preclinica, Immunosuppressant Analogs in Neuroprotection
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  • Immunosuppressant Analogs in Neuroprotection
  • Written by author Cesario V. Borlongan
  • Published by Springer-Verlag New York, LLC, October 2007
  • An authoritative survey of the most recent scientific evidence showing how cyclosporin, FK-506, and their analogs-the neuroimmunophilins-evolved from being purely immunosuppressant "drugs" to neuroprotective "agents". The book focuses on recent preclinica
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Authors

Foreword
Preface
Contributors
Pt. IImmunosuppressants, Neurologic Disorders, and Neuroprotection
1Introduction: Immunosuppressants as Neuroprotective Agents3
Pt. IIImmunosuppressants and Parkinson's Disease
2Cyclosporin-Mediated Amelioration of Degeneration of Dopaminergic Neurons in Experimental Models of Parkinsonism35
3Immunophilin Ligands and Dopamine Neurons: Specific Effects in Culture and In Vivo49
4Effects of Neuroimmunophilin Ligands on Parkinson's Disease and Cognition67
5Improved Survival of Grafted Dopamine Neurons by Calcineurin Inhibitors93
6Possible Mechanisms Underlying the Protective Action of Immunosuppressants Against Parkinson's Disease: The Mitochondrial Permeability Transition Pore Hypothesis105
Pt. IIIImmunosuppressants and Other Age-Related Disorders
7Immunosuppressants and Alzheimer's Disease141
8Cyclosporin A Protects Striatal Neurons from Mitochondrial Dysfunction: Implications for Huntington's Disease159
Pt. IVImmunosuppressants, Stroke, and Traumatic Brain Injury
9Cyclosporin A Protects Mitochondria in an In Vitro Model of Hypoxia/Reperfusion Injury177
10Protective Effect of Cyclosporin A on Glial Activation and White Matter Alterations Induced by Chronic Cerebral Hypoperfusion193
11Blockade of Late-Onset Reduction of Muscarinic Acetylcholine Receptors by Immunosuppressants in Forebrain Ischemia215
12The Role of Immunophilins in Focal Cerebral Ischemia: Evidence of Neuroprotection by FK506231
13Immunosuppressants in Traumatic Brain Injury263
Pt. VImmunosuppressants and Spinal Cord Injury
14Inhibition of Lipid Peroxidation by Cyclosporin After Spinal Cord Injury in Rats283
15Axonal Regeneration in Cyclosporin A-Treated Rats Submitted to Transverse Section of the Spinal Cord299
Pt. VIImmunosuppressants and Sciatic Nerve Injury
16Neuroimmunophilin Ligands Accelerate and Promote Nerve Regeneration in the Rat Peripheral Nerve and Spinal Cord: Role of the Steroid Receptor-FKBP52 Complex317
17Neuroimmunophilin Ligands Stimulate Recovery of Injured Sciatic Nerves329
Pt. VIIImmunosuppressants and Other Disorders of the Central Nervous System
18Cyclosporin A Prolongs Survival of SOD1 Mutant Mice and Implicates Mitochondrial Permeability Transition in Amyotrophic Lateral Sclerosis343
19Psychological Effects of Cyclosporin A361
Index375


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Immunosuppressant Analogs in Neuroprotection, An authoritative survey of the most recent scientific evidence showing how cyclosporin, FK-506, and their analogs-the neuroimmunophilins-evolved from being purely immunosuppressant drugs to neuroprotective agents. The book focuses on recent preclinica, Immunosuppressant Analogs in Neuroprotection

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Immunosuppressant Analogs in Neuroprotection, An authoritative survey of the most recent scientific evidence showing how cyclosporin, FK-506, and their analogs-the neuroimmunophilins-evolved from being purely immunosuppressant drugs to neuroprotective agents. The book focuses on recent preclinica, Immunosuppressant Analogs in Neuroprotection

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Immunosuppressant Analogs in Neuroprotection, An authoritative survey of the most recent scientific evidence showing how cyclosporin, FK-506, and their analogs-the neuroimmunophilins-evolved from being purely immunosuppressant drugs to neuroprotective agents. The book focuses on recent preclinica, Immunosuppressant Analogs in Neuroprotection

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