Genetically Engineered Vaccines Book

	Introductory Address
	The New Biology and Vaccine Research	1
	Keynote Presentation
	Mucosal Immunity to Vaccines: Current Concepts for Vaccine Development and Immune Response Analysis	3
Sess. I	Oral Diseases and Host Immune Responses
	Prospects for Human Mucosal Vaccines	13
	Bacterial Diseases of the Oral Tissues	25
	Oral Virus Infections: The Potential for Gene Transfer in Treatment and Prevention	35
Sess. II	Update on Vaccines and Vaccine Development
	Bacterial Mucosal Vaccines	43
	A General Overview of Viral Vaccine Development	51
Sess. III	Vaccines and the Mucosal Immune System
	An Update on the "Jennerian" And Modified "Jennerian" Approach to Vaccination of Infants and Young Children Against Rotavirus Diarrhea
	Induction of Mucosal and Serum Immune Responses to a Specific Antigen of Periodontal Bacteria	71
	IgA1 Proteases and Host-Parasite Relationships in the Oral Cavity	83
	Transport of IgA Immune Complexes Across Epithelial Membranes: New Concepts in Mucosal Immunity	91
	Effect of Mucosal Microenvironment on Immune Response to Viruses	95
Sess. IV	Optimizing Mucosal and Systemic Immune Responses
	Induction of T Helper Cells and Cytokines for Mucosal IgA Responses	107
	Cytokine Production and T Cell Receptor Expression by Salivary Gland T Cells and Intraepithelial T Lymphocytes for the Regulation of the IgA Response	119
	Immunological Adjuvants	133
Sess. V	Delivery Systems and Immune Analysis
A	Passive Immunity
	M Cell-Mediated Antigen Transport and Monoclonal IgA Antibodies for Mucosal Immune Protection	143
	A Mechanism of Passive Immunization with Monoclonal Antibodies to a 185,000 M[subscript r] Streptococcal Antigen	151
B	Active Immunity
	Delivery of Antigens by Recombinant Avirulent Salmonella Strains	165
	Use of Recombinant BCG as a Vaccine Delivery Vehicle	175
	Vaccinia Virus Recombinants as Potential Herpes Simplex Virus Vaccines	183
	Liposomes and Conjugate Vaccines for Antigen Delivery and Induction of Mucosal Immune Responses	191
	Peroral Immunization With a Cholera Toxin-Linked Bacterial Protein Antigen and Synthetic Peptide	199
	Peptomers as Vaccine Candidates	209
Sess. VI	Target Antigen Selection and Vaccine Development
	Structural and Functional Studies of Herpes Simplex Virus Glycoprotein D	217
	Molecular, Immunological and Functional Characterization of the Major Surface Adhesin of Streptococcus Mutans	229
	Reactive Antigens of the Periodontopathic Bacterium Actinobacillus Actinomycetemcomitans	243
	Immunization With Fimbrial Protein and Peptide Protects Against Porphyromonas Gingivalis-Induced Periodontal Tissue Destruction	255
	Vaccine Development: Progression from Target Antigen to Product	263
Sess. VII	Immunological Correlates of Protection
	Significance of Immune Responses to Oral Antigens in Dental Diseases	273
	Laboratory Correlates of Protection and Protective Immunity to Bordetella Pertussis	287
	Future Directions
	Challenges and Opportunities in Vaccine Research	293
	Summary and Recommendations for Future Research	301
	Speakers and Moderators	315
	Author Index	319
	Subject Index	321