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Strategies and techniques - general methods, Robert F. Weaver, cloning strategies, Richard Intres and John W. Crabb, protein engineering strategies, Marc Whitlow, general strategies in in vivo animal modelling, Daniel A. Vallera and Bruce R. Blazar; ricin - molecular cloning of ricin, Lynne R. Roberts, et al, expression of plant-derived ribosome-inactivating proteins in heterologous systems, Michael Piatak, Jr, and Noriyuki Habuka, the structure of plant toxins as a guide to rational design, Jon D. Robertus, chemical and genetic characterization of the enzymatic activity associated with ricin A chain, Lawrence Greenfield, chimeric proteins containing ricin A chain, J. Michael Lord, et al; plant hemitoxins - studies on ribosome-inactivating proteins from Saponaria officinalis, Marco R. Soria, et al, cloning and expression of trichosanthin and - momorcharin cDNA, Pang-Chui shaw, et al, cloning and expression of a Luffa ribosome-inactivating-related protein, Bi-Yu Li and S. Ramakrishnan; fungal ribotoxins - the Aspergillus ribonucleolytic toxins (ribotoxins), Bernard Lamy, et al, an efficient expression system for -sarcin in Escherichia coli, Yaeta Endo, et al; diphtheria toxin - diphtheria toxin cloning and expression in corynebacterium diphtheriae, Lawrence Greenfield, diphtheria toxin expression in Escherichia coli, Lawrence Greenfield, the structure of diphtheria toxin as a guide to rational design, Peter J. Nicholls and Richard J. Youle, protein engineering of diphtheria toxin - development of receptor-specific cytotoxic agents for the treatment of human disease, John R. Murphy , et all, in vivo studies with chimeric toxins - interleukin-2 fusion toxins as immunosuppressive agents, Michael E. Shapiro, et al, initial clinical experiences with an interleukin-2 fusion toxin (DAB 486-IL-2), Carole M. Meneghetti and C.F. Le Maistre; pseudomonas exotoxins - pseudomonas aeruginosa exotoxin A, G. Jiliani Chaudry, et al, expression of growth factor - toxin fusion proteins, Gwynneth M. Edwards, et al, the structure of pseudomonas exotoxin A as a guide to rational design, Peter J. Nichols and Richard J. Youle, generation of chimeric toxins, David FitzGerald, et al; conclusions - genetically engineered toxins in perspective, Sjur Olsnes and Arthur E. Frankel, Appendix - primary amino acid sequences of toxins, Paul Sehnke and Alexander Tonevistsky.
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Daniel Dion
reviewed Genetically Engineered Toxins on May 23, 2020 Genetically Engineered Toxins
FAAAASCINATING. Honestly, I kept pestering Kent, "Listen to this..." and then reading a paragraph or two. It's about the science of how the brain and body connect. We have "body maps" in our brain, that tell us exactly where our body parts are, and how they are doing. (This is why we can touch our nose with our eyes closed.) It doesn't sound interesting, until you read what this means, in practical applications. And the stuff about how our homonulcus (body maps) go awry is just astonishing.
Body mapping accounts for why we can ride a horse, why we duck a little when we drive our cars into a garage with low clearance, why we feel afraid in scary movies, and also things like autism (mirror neuron defects).
Here's an example: if you took a perfectly healthy kitten, and then carried it around with you wherever you went, exposing it to many sights and sounds, but not allowing it to interact with it's environment, that kitten would be blind. It would still "see" colors and shapes and everything, but it's brain would have no context for interpreting that input, so the cat would be just as blind as a cat with no eyes. Bizarre, huh? Here's another: the women in Mali think it's important for their children to have straight legs so several times a day, from birth onwards, they massage and pull on their infants' legs, pulling them straight. Guess the average age of walking? EIGHT MONTHS. Because those kids' body maps of their legs got so much stimulation from the environment as they were developing. Contrast that with kids in orphanages in the Eastern Block countries who are left alone in their cribs for days on end. Those kids are unable to stand on one foot without toppling over. Why? Because their leg body maps are so woefully undeveloped because there was no opportunity for interaction with their environment.
Anyhow, it's really an interesting read, runs a gamut of really diverse topics, all having to do with our body maps, and it's not very long (about 200 pages.) I really recommend it.
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Add Genetically Engineered Toxins, Presenting all preclinical and clinical information available on genetically engineered toxins, this unique, single-source reference provides the most up-to-date methods and practical examples for conducting clinical studies in toxin molecular biology.;Re, Genetically Engineered Toxins to the inventory that you are selling on WonderClubX
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Add Genetically Engineered Toxins, Presenting all preclinical and clinical information available on genetically engineered toxins, this unique, single-source reference provides the most up-to-date methods and practical examples for conducting clinical studies in toxin molecular biology.;Re, Genetically Engineered Toxins to your collection on WonderClub |