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Contributors | iii | |
Preface | v | |
Introduction | vii | |
1. | General Concepts of Molecular Diffusion | 1 |
I. | Introduction | 1 |
II. | General Description of Gaseous Diffusion | 3 |
III. | Physical Basis of Molecular Diffusion | 4 |
IV. | Phenomenological Laws of Molecular Diffusion | 8 |
V. | Summary | 20 |
References | 21 | |
2. | Anatomical Factors Influencing Gas Mixing and Distribution | 23 |
I. | Introduction | 23 |
II. | The Conducting Airways | 24 |
III. | The Acinus | 43 |
IV. | Airway Cross-Sectional Area | 49 |
V. | Asymmetry and Function | 49 |
VI. | Diseased Lungs | 50 |
References | 57 | |
3. | Gas Transport in the Conducting Airways | 63 |
I. | Scope | 63 |
II. | Background | 64 |
III. | Theoretical Basis of Mixing Experiments | 86 |
IV. | Mixing Experiments | 98 |
V. | Applications | 117 |
VI. | Summary | 126 |
Nomenclature | 127 | |
References | 129 | |
4. | Alveolar Ventilation at High Frequencies Using Tidal Volumes Smaller than the Anatomical Dead Space | 137 |
I. | Introduction | 137 |
II. | Historical Review | 138 |
III. | Mechanisms of Gas Transport | 141 |
IV. | Measurements of Gas Transport in Hardware Models | 151 |
V. | Theories of Gas Exchange During HFV | 155 |
VI. | Physiological Studies | 161 |
VII. | Summary and Conclusions | 171 |
References | 172 | |
5. | Regional Ventilation Distribution | 177 |
I. | Introduction | 177 |
II. | Theory and Methods | 178 |
III. | Distribution of Ventilation in Normal Subjects | 183 |
IV. | Regional Lung Expansion in Normal Subjects | 191 |
V. | Residual Volume | 197 |
VI. | Anesthesia and Muscle Paralysis | 200 |
VII. | Distribution of Ventilation in Lung Disease | 204 |
VIII. | Mechanisms | 207 |
References | 212 | |
6. | Theoretical Studies of Gas Mixing in the Lung | 221 |
I. | Introduction | 221 |
II. | Diffusion Equation | 225 |
III. | Trumpet Model | 232 |
IV. | Two-Trumpet or One-Branch-Point Model | 253 |
V. | Multibranch-Point Models | 272 |
VI. | Conclusions | 279 |
References | 281 | |
7. | Intraregional Gas Mixing and Distribution | 287 |
I. | Introduction | 287 |
II. | Historical Aspects | 288 |
III. | Mechanisms of Gas Mixing | 289 |
IV. | Potential Mechanisms of Gas Mixing Inhomogeneity | 290 |
V. | Single-Breath Inert Gas Washout | 295 |
VI. | Multiple-Breath Inert Gas Washout | 311 |
VII. | Other Experimental Approaches | 342 |
VIII. | Summary | 348 |
References | 349 | |
8. | Distribution and Mixing in Gas-Exchange Organs of Nonmammalian Vertebrates | 359 |
I. | Introduction | 359 |
II. | Birds | 360 |
III. | Fish | 374 |
IV. | Mammals versus Birds and Fish: Search for Similarities | 383 |
References | 386 | |
Concluding Remarks | 393 | |
Author Index | 397 | |
Subject Index | 411 |
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Add Gas mixing and distribution in the lung, This impressive volume presents a state-of-the-art synthesis of all aspects of gas mixing and ventilation distribution in the lung, blending current theoretical understanding with the most recent experimental findings for complete coverage unavailable in , Gas mixing and distribution in the lung to your collection on WonderClub |