Enzyme Mechanism from Isotope Effects Book

THEORETICAL BASIS FOR ISOTOPE EFFECTS. Theoretical Basis for Primary and Secondary Hydrogen Isotope Effects. Origins and Interpretations of Heavy-Atom Isotope Effects. Theoretical Basis and Mechanistic Utility of Solvent Isotope Effects. Hydrogen Tunneling and Coupled Motion in Enzyme Reactions. ISOTOPE EFFECTS IN ENZYME-CATALYZED REACTIONS. Isotope Effects on the Transient Kinetics of Enzyme Reactions. Instrinsic Isotope Effects in Enzyme-Catalyzed Reactions. Kinetic and Regulatory Mechanisms of Enzymes from Isotope Effects. pH Dependence of Isotope Effects in Enzyme-Catalyzed Reactions. Multiple Isotope Effects in Enzyme-Catalyzed Reactions. METHODS FOR THE DETERMINATION OF ISOTOPE EFFECTS (LIMITED APPLICATIONS). Methods for the Determination of Competitive and Noncompetitive Kinetic Isotope Effects. Heavy Atom Isotope Effects Using the Isotope Ratio Mass Spectrometer. Use of the Stable Isotope Remote Label Technique to Determine Isotope Effects in Enzyme-Catalyzed Reactions. Measuring the Gram-Atom Percent of Deuterium in Heavy Water by Absorption Spectroscopy. ISOTOPE EFFECTS IN SPECIFIC ENZYMIC REACTIONS. Isotope Effects on Enzyme-Catalyzed Redox Reactions. Kinetic Isotope Effects for Hydrolase Reactions. Isotope Effects on Enzyme Catalyzed b-Eliminations. Isotope Effects in Enzyme-Catalyzed Group Transfer Reactions. Triosephosphate Isomerase and Proline Racemase: Revelation of Reaction Energetics. Isotope Effects in Reactions Catalyzed by Thymidylate Synthase.