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Drug Resistance Book

Drug Resistance
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Drug Resistance, Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity , Drug Resistance
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  • Drug Resistance
  • Written by author William N. Hait
  • Published by Springer-Verlag New York, LLC, 7/31/2012
  • Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity
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Authors

List of Contributors
Introduction
1 P-Glycoprotein-Mediated Multidrug Resistance: Experimental and Clinical Strategies for its Reversal 3
2 Multidrug Resistance Associated with Overexpression of MRP 39
3 Mechanisms of Resistance to Alkylating Agents 65
4 Glutathione S-Transferases 83
5 Role of DNA Repair in Resistance to Drugs that Alkylate O[superscript 6] of Guanine 123
6 Paclitaxel (Taxol): Mechanisms of Resistance 149
7 Mechanisms of Clinical Resistance to 5-Fluorouracil Chemotherapy 175
8 Antifolates: Current Developments 197
9 Human Immunodeficiency Virus Replication in the Presence of Antiretroviral Drugs: Analogies to Antineoplastic Drug Resistance 225
10 Cellular Resistance to Topoisomerase Poisons 243
11 Acquisition of an Antiestrogen Resistant Phenotype in Breast Cancer: Role of Cellular and Molecular Mechanisms 263
12 Androgen Receptor Mutations in Prostate Cancer 285
13 Retinoids in Clinical Cancer Therapy 305
14 Apoptosis and Cancer Chemotherapy 345
15 Interaction of Chemotherapy and Biological Response Modifiers in the Treatment of Melanoma 357
16 Multifunctional Modulators of Drug Resistance 381
Index 409


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Drug Resistance, Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity , Drug Resistance

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Drug Resistance, Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity , Drug Resistance

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Drug Resistance, Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity , Drug Resistance

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