Cutaneous Oncology Book

	Preface	v
	Foreword	vii
	Contributors	xv
Part I	Cutaneous Carcinogenesis	1
1.	History of Cutaneous Carcinogenesis	2
2.	Multistage Mouse Model of Skin Carcinogenesis and Cell Cycle Regulation	8
3.	Molecular Model of Cancer Development	19
4.	Development of Metastases	30
5.	Immune Surveillance Mechanisms	39
6.	Skin Cancer in the Immunosuppressed Host	51
7.	Differentiation Pathways	61
8.	Cytokines and Growth Factors	73
9.	Retinoids	87
10.	The Role of Aging	92
11.	Tumor-Stroma Interactions	98
12.	Tumor Dormancy	105
13.	DNA Damage and Repair	110
14.	Mechanisms of Ultraviolet Radiation: Carcinogenesis and Immune Suppression	115
15.	Epidemiology of Ultraviolet Radiation	121
16.	The Ozone Layer	129
17.	Ionizing Radiation	134
18.	Chemicals	141
19.	Viruses	148
20.	Genetic Syndromes Predisposing to Skin Cancer Development	158
21.	The Public Health Approach to Prevention of Skin Cancer	169
22.	Chemoprevention of Skin Cancer	175
Part II	Melanoma	179
23.	History of Melanoma	180
24.	Molecular Biology	183
25.	Cell Structure and Function	200
26.	Cellular Immunobiology	211
27.	Biologic Factors	218
28.	Precursor Melanocytic Lesions	224
29.	Environmental and Host Risk Factors	235
30.	Pregnancy and Estrogen	243
31.	Follow-up Evaluation of Patients at Risk	250
32.	Clinical Presentation	253
33.	Histology	262
34.	Factors Predictive of Metastasis and Outcome	278
35.	Clinical Presentation and Diagnosis of Metastasis	292
36.	Therapy of Melanoma In-situ (Lentigo Maligna)	297
37.	Surgical Treatment of Stage I and II Disease (Excision, Lymphadenectomy, Limb Perfusion)	303
38.	Radiation Therapy of Stage I and II Disease	316
39.	Adjuvant Therapy of Stage I and II Disease	323
40.	Therapy of Stage III and IV Disease	331
41.	New Horizons and Research Techniques	342
Part III	Squamous Cell Carcinoma	349
42.	History of Squamous Cell Carcinoma	350
43.	Molecular Biology	353
44.	Cell Structure and Function	361
45.	Cellular Immunobiology	373
46.	Effects of Biological Factors	379
47.	Risk Factors	382
	Color Plates Section	391
48.	Predisposing Genetic Syndromes and Clinical Settings	457
49.	Clinical Presentation	468
50.	Histology	481
51.	Features Associated with Recurrence	494
52.	Features Associated with Metastasis	500
53.	Surgical Management of Local Disease	506
54.	Cryosurgery	518
55.	Radiation Therapy	526
56.	Lasers and Photodynamic Therapy	534
57.	Biologic Response Modifiers	542
58.	Topical Chemotherapy	547
59.	Surgery and Radiation Therapy for Advanced Disease	553
60.	Chemotherapy and Biologic Response Modifiers for Advanced Disease	558
61.	Follow-up and Prevention	565
62.	Research Techniques and New Horizons	571
Part IV	Basal Cell Carcinoma	577
63.	History of Basal Cell Carcinoma	578
64.	Pathogenesis	581
65.	Molecular Genetics	586
66.	Cell Structure and Function	592
67.	Cellular Immunobiology	599
68.	Biologic Factors	604
69.	Aggressive versus Nonaggressive Subtypes	609
70.	Risk Factors	614
71.	Predisposing Genetic Syndromes and Clinical Settings	619
72.	Clinical Presentation	625
73.	Histology	633
74.	Features Associated with Recurrence	646
75.	Features Associated with Metastasis	657
76.	Surgical Management of Local Disease	664
77.	Cryosurgery	672
78.	Radiation Therapy of Local Disease	676
79.	Lasers and Photodynamic Therapy	678
80.	Biologic Response Modifiers	681
81.	Topical Chemotherapy	687
82.	Adjuvant Therapy of Local Disease	691
83.	Follow-up and Prevention	695
84.	Regional and Distant Metastatic Disease	699
85.	Research Techniques and New Horizons	702
Part V	Other Cutaneous Tumors	709
86.	Merkel Cell Carcinoma	710
87.	Microcystic Adnexal Carcinoma	722
88.	Primary Cutaneous Adenoid Cystic Carcinoma	729
89.	Malignant Eccrine Spiradenoma	734
90.	Malignant Clear Cell Hidradenoma	738
91.	Malignant Chondroid Syringoma	745
92.	Eccrine Porocarcinoma	752
93.	Eccrine Mucinous Carcinoma	758
94.	Malignant Cylindroma	763
95.	Malignant Hidradenoma Papilliferum	769
96.	Apocrine Carcinoma	772
97.	Paget's Disease of the Nipple	781
98.	Extramammary Paget's Disease	789
99.	Malignant Ceruminoma	796
100.	Sebaceous Gland Carcinoma	800
101.	Pilomatrix Carcinoma	811
102.	Overview of Soft-Tissue Sarcomas	816
103.	Dermatofibrosarcoma Protuberans	822
104.	Fibrosarcoma	832
105.	Atypical Fibroxanthoma	835
106.	Malignant Fibrous Histiocytoma	844
107.	Liposarcoma	852
108.	Angiosarcoma	861
109.	Kaposi's Sarcoma	873
110.	Hemangiopericytoma	887
111.	Leiomyosarcoma	893
112.	Cutaneous Rhabdomyosarcoma	897
113.	Malignant Peripheral Nerve Sheath Tumor	902
114.	Malignant Granular Cell Tumor	907
115.	Epithelioid Sarcoma	915
116.	Cutaneous T-Cell Lymphoma	921
117.	Cutaneous B-Cell Lymphomas	954
118.	Cancers Metastatic to the Skin	964
	Index	973