Clinical significance and potential of selective COX-2 inhibitors Book

This volume is the combined proceedings of the William Harvey Conferences held in Phuket, Thailand on 18 and 19 September 1997 and in Boston, USA on 23 and 24 April 1998. It reviews the current knowledge of the role of cyclooxygenase-2 in inflamed joints, cancers, Alzheimer's disease and parturition and presents data to demonstrate how the gastrointestinal and renal toxicity of non-steroid antiinflammatory drugs can be avoided by the use of preferential inhibitors of cyclooxygenase-2. Sir John Vane is the Honorary President and Dr Regina Botting a Research Fellow at the William Harvey Research Institute, an independent charitable foundation within Queen Mary and Westfield College of the University of London. Sir John Vane shared the Nobel Prize in Physiology or Medicine in 1982 for his discoveries in the prostaglandin field, including prostacyclin and the mechanism of action of aspirin.