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Chemical Creativity: Ideas from the Work of Woodward, Hckel, Meerwein, and Others Book

Chemical Creativity: Ideas from the Work of Woodward, Hckel, Meerwein, and Others
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  • Chemical Creativity: Ideas from the Work of Woodward, Hckel, Meerwein, and Others
  • Written by author Jerome A. Berson
  • Published by Wiley, John & Sons, Incorporated, June 1999
  • Where are the origins of chemical ideas? How did the pioneers in chemistry recognize the fundamental intellectual issues of their time? What skills of reasoning and experiment did they use to solve these problemes? How did the circumstances of personality
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Introduction: The Nature of Science and the History of Science/An Experiment.
Discoveries Missed, Discoveries Made - Two Case Studies of Creativity in Chemistry: Science and the Individual/Diels, Alder, Their Competitors, and the Discovery of the Diene Synthesis/Thiele/The Alternation Effect and the Discovery of Orbital Symmetry.
Erich Huckel and the Theory of Aromaticity - Reflections on Theory and Experiment: Debye-Huckel Theory of Electrolytic Solutions/Nature of the Double Bond/Hybridization in Double Bonds/Benzene Problem/MO Description of Conjugated Cyclic Compounds/Orbital Symmetry (Woodward-Hoffmann Rules)/ Extension of Cyclic p-Electron MO Theory to Transition States of Pericyclic Reactions/Violation of Hund's Rule in Biradicals/Reflections on Huckel's Career.
The Dienone-Phenol Mysteries: Isolations of Estrogens/Approaches to the Estrogens by Aromatization of Ring A/ Alicyclic Steroids/Woodward's Challenge/Misgivings About the Structures/Why did Woodward Undertake the Correction of the Phenolic Structures?/Woodward and the Total Synthesis of Steriods/Approaches and Achievements/Mechanistic Motivation.
Meditations on the Special Convictive Power of Symmetrization Experiments: Enolization as a Mechanism of Symmetrization/The Menthone Problem/Tricyclene and the Wagner-Meerwein Rearrangement/The Pinacol Controversy/The Favorskii Rearrangement/Symmetrization/Racemization Machines with no Achiral Parts/Direct Nucleophilic Displacement Reaction/The Walden Inversion/Biological and Evolutionary Attraction of Symmetry.
Epilogue.


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