Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery Book

I. Introduction

The Need for New Approaches to Antimalarial Chemotherapy

Philip J. Rosenthal and Louis H. Miller

The History of Antimalarial Drugs

Steven R. Meshnick and Mary J. Dobson

Transport and Trafficking in Plasmodium-Infected Red Cells

Kasturi Haldar and Thomas Akompong

The Plasmodium Food Vacuole

Ritu Banerjee and Daniel E. Goldberg

Clinical and Public Health Implications of Antimalarial Drug Resistance

Piero L. Olliaro and Peter B. Bloland

II. Established Antimalarial Drugs and Compounds Under Clinical Development

Chloroquine and Other Quinoline Antimalarials

Leann Tilley, Paul Loria, and Mick Foley

8-Aminoquinolines

Ralf P. Brueckner, Colin Ohrt, J. Kevin Baird, and Wilbur K. Milhous

Mechanisms of Quinoline Resistance

Grant Dorsey, David A. Fidock, Thomas E. Wellems, and Philip J. Rosenthal

Folate Antagonists and Mechanisms of Resistance

Christopher V. Plowe

Artemisinin and Its Derivatives

Steven R. Meshnick. Atovaquone-Proguanil Combination, Akhil B. Vaidya

The Antimalarial Drug Portfolio and Research Pipeline

Piero L. Olliaro and Wilbur K. Milhous

III. New Compounds, New Approaches, and New Targets

Novel Quinoline Antimalarials

Paul A. Sks, Kaylene J. Raynes, and Stephen A. Ward

New Antimalarial Trioxanes and Endoperoxides

Gary H. Posner, Mikhail Krasavin, Michael McCutchen, Poonsakdi Ploypradith, John P. Maxwell, Jeffrey S. Elias, and Michael H. Parker

Antibiotics and the Plasmodial Plastid Organelle

Barbara Clough and R. J. M. (Iain) Wilson

Fresh Paradigms for Curative Antimetabolites

Pradipsinh K. Rathod. Iron Chelators, Mark Loyevsky and Victor R. Gordeuk

Protease Inhibitors

Philip J. Rosenthal

Inhibitors of Phospholipid Metabolism

Henri Joseph Vial and Michèle Calas

Development of New Malaria Chemotherapy by Utilization of Parasite-Induced Transport

Annette M. Gero and Alexander L. Weis