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Tumor Prevention and Genetics Book

Tumor Prevention and Genetics
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Tumor Prevention and Genetics, This book presents a comprehensive update of the latest findings in oncogenetics. It also investigates the relevance of preclinical models with respect to clinical cancer prevention (primary and secondary) for major cancer types such as breast, skin, lung, Tumor Prevention and Genetics
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  • Tumor Prevention and Genetics
  • Written by author Hans-J
  • Published by Springer, 2003/05/08
  • This book presents a comprehensive update of the latest findings in oncogenetics. It also investigates the relevance of preclinical models with respect to clinical cancer prevention (primary and secondary) for major cancer types such as breast, skin, lung
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Introduction 1
Genetic Susceptibility, Predicting Risk and Preventing Cancer 7
Novel Approaches to Identify Low Penetrance Cancer Susceptibility Genes Using Mouse Models 19
Development of Novel Selective Cell Ablation in the Mammary Gland and Brain to Study Cell-Cell Interactions and Chemoprevention 31
Mouse Skin as a Model for Cancer Chemoprevention by Nonsteroidal Anti-Inflammatory Drugs 46
Preclinical Models for Chemoprevention of Colon Cancer 58
New Cancer Biomarkers Deriving from the NCI Early Detection Research 72
Tamoxifen's Impact as a Preventive Agent in Clinical Practice and an Update on the STAR Trial 87
Aromatase Inhibitors in Prevention - Data from the ATAC (Arimidex, Tamoxifen Alone or in Combination) Trial and the Design of IBIS-II (The Second International Breast Cancer Intervention Study) 96
HRT Opposed by Low Dose Tamoxifen (HOT Study). Rationale and Design 104
Is Mammography Screening for Breast Cancer Really Not Justifiable? 115
How Reliable is the Evidence for Screening Mammography? 129
Political Interpretation of Scientific Evidence - Case Study of Breast Cancer Screening Policies Around the World 140
Skin Cancer Chemoprevention: Strategies to Save our Skin 151
Chemoprevention of Non-Melanoma Skin Cancer: Experience with a Polyphenol from Green Tea 165
Chemoprevention of Lung Cancer: New Directions 172
Key Issues in Lung Cancer Chemoprevention Trials of New Agents 182
Prevention of Prostate Cancer 199
Clinical Models for Testing Chemopreventative Agents in Prostate Cancer and Overview of SELECT: The Selenium and Vitamin E Cancer Prevention Trial 212
Problems with Prostate Specific Antigen Screening: A Critical Review 226
Genetic Predisposition as a Basis for Chemoprevention, Surgical and Other Interventions in Colorectal Cancer 235
Fecal Occult Blood (FOB) Screening - Trial Evidence, Practice and Beyond 248
Is FOB-Screening Really the Answer for Lowering Mortality in Colorectal Cancer? 254
Summary and Conclusions 264


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Tumor Prevention and Genetics, This book presents a comprehensive update of the latest findings in oncogenetics. It also investigates the relevance of preclinical models with respect to clinical cancer prevention (primary and secondary) for major cancer types such as breast, skin, lung, Tumor Prevention and Genetics

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Tumor Prevention and Genetics, This book presents a comprehensive update of the latest findings in oncogenetics. It also investigates the relevance of preclinical models with respect to clinical cancer prevention (primary and secondary) for major cancer types such as breast, skin, lung, Tumor Prevention and Genetics

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Tumor Prevention and Genetics, This book presents a comprehensive update of the latest findings in oncogenetics. It also investigates the relevance of preclinical models with respect to clinical cancer prevention (primary and secondary) for major cancer types such as breast, skin, lung, Tumor Prevention and Genetics

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