Infrared and Raman Spectroscopic Imaging Book

Preface.

List of Contributors.

Part One: Basic Methodology.

1 Infrared and Raman Instrumentation for Mapping and Imaging (Peter R. Griffiths).

1.1 Introduction to Mapping and Imaging.

1.2 Mid-Infrared Microspectroscopy and Mapping.

1.3 Raman Microspectroscopy and Mapping.

1.4 Near-Infrared Hyperspectral Imaging.

1.5 Raman Hyperspectral Imaging.

1.6 Mid-Infrared Hyperspectral Imaging.

1.7 Mapping with Pulsed Terahertz Radiation.

1.8 Summary.

Acknowledgments.

References.

2 Chemometric Tools for Image Analysis(Anna de Juan, Marcel Maeder, Thomas Hancewicz, Ludovic Duponcheland Romà Tauler).

2.1 Introduction.

2.2 Hyperspectral Images: The Measurement.

2.3 Image Preprocessing.

2.4 Exploratory Image Analysis.

2.5 Quantitative Image Information: Multivariate Image Regression (MIR).

2.6 Image Segmentation.

2.7 Image Resolution.

References.

Part Two: Biomedical Applications.

3 Vibrational Spectroscopic Imaging of Soft Tissue (Christoph Krafft).

3.1 Introduction.

3.2 Preparation of Soft Tissue for Vibrational Spectroscopic Imaging.

3.3 Applications to Soft Tissues.

3.4 Conclusions.

References.

4 Vibrational Spectroscopic Imaging of Hard Tissues (Michael D. Morris, Matthew V. Schulmerich, Kathryn A. Dooley, and Karen A. Esmonde-White).

4.1 Infrared and Raman Spectroscopy of Bone.

4.2 Infrared and Raman Imaging of Bone.

4.3 Infrared and Raman Spectroscopy of Cartilage.

4.4 Infrared and Raman Imaging of Cartilage.

4.5 Conclusions.

References.

5 Infrared and Raman Spectroscopy and Spectral Imaging of Individual Cells (Max Diem, Christian Matthäus, Tatyana Chernenko, Melissa J. Romeo,Miloš Miljkovic´, Benjamin Bird, Jennifer Schubert, Kostas Papamarkakis,and Nora Laver).

5.1 Introduction.

5.2 Methods.

5.3 Results and Discussion.

5.4 Conclusions.

Acknowledgments.

References.

6 3-D Imaging of Biomedical Samples (Don McNaughton, Bayden R. Wood, Timothy C. Cox,Jörg-Detlef Drenckhahn, and Keith R. Bambery).

6.1 Introduction.

6.2 Methodologies.

6.3 Resultant 3-D Images.

6.4 Conclusions.

Acknowledgments.

References.

Part Three: Agricultural Applications.

7 FT-IR Microspectroscopic Imaging of Plant Material (David L. Wetzel).

7.1 Introduction, Background and Perspective.

7.2 Application of IMS to Kernels and Seeds of Plants.

7.3 Leaves.

7.4 Application of IMS to Stems and Cellulose Polymers.

7.5 Algae.

7.6 Comments.

Acknowledgments.

References.

8 Near-Infrared Hyperspectral Imaging in Food and Agricultural Science (Véronique Bellon Maurel and Janie Dubois).

8.1 Introduction.

8.2 At the Laboratory Scale.

8.3 At the Industrial Scale.

8.4 General Conclusions.

References.

Part Four: Polymers and Pharmaceuticals

9 FT-IR and NIR Spectroscopic Imaging: Principles, Practical Aspects and Applications in Material and Pharmaceutical Sciences (Elke Wessel, Christian Vogel, Olga Kolomiets, Uwe Hoffmann, and Heinz W. Siesler).

9.1 Introduction.

9.2 Instrumentation for FT-IR and NIR Imaging.

9.3 Applications of FT-IR Imaging for Polymer Research and Quality Control.

9.4 NIR Imaging Spectroscopy for Quality Control of Pharmaceutical Drug Formulations.

References.

10 ATR-FT-IR Imaging for Pharmaceutical and Polymeric Materials: From Micro to Macro Approaches (Sergei G. Kazarian, K. L. Andrew Chan, and Feng H. Tay).

10.1 Introduction.

10.2 The Versatility of ATR-FT-IR Imaging.

10.3 Applications of ATR-FT-IR Imaging in the Materials Sciences.

10.4 Applications of ATR-FT-IR Imaging in the Pharmaceutical Sciences.

10.5 ATR-FT-IR Imaging for Forensic Applications.

10.6 Conclusions and Outlook.

References.

11 Raman Spectral Imaging on Pharmaceutical Products (Eunah Lee).

11.1 Overview.

11.2 Hyperspectral Imaging.

11.3 Empirical Approach to Successful Raman Hyperspectral Imaging.

11.4 Raman in Multimodal Hyperspectral Imaging.

11.5 Conclusions.

Acknowledgments.

References.

Part Five: Developments in Methodology.

12 Deep, Noninvasive Raman Spectroscopy of Diffusely Scattering Media(Pavel Matousek).

12.1 Introduction.

12.2 Techniques for Deep, Noninvasive Raman Spectroscopy.

12.3 Examples of Application Areas.

12.4 Outlook on Raman Tomography.

12.5 Conclusions.

Acknowledgments.

References.

13 Planar Array Infrared Spectroscopy and 1-D Imaging (Christian Pellerin).

13.1 Introduction.

13.2 Concept and Instrumentation.

13.3 PA-IR Spectroscopy.

13.4 Applications.

13.5 Conclusions.

References.

14 Biomedical Applications of Infrared Microspectroscopy Using Synchrotron Radiation (Lisa M. Miller).

14.1 Introduction.

14.2 Spatial Resolution Considerations.

14.3 Advantages of a Synchrotron IR Source.

14.4 Instrumentation.

14.5 Biological Sample Preparation and Modes of Data Collection.

14.6 Biological and Medical Applications of Synchrotron IR Microspectroscopy.

14.7 Future Directions for Synchrotron IR Microspectroscopy.

Acknowledgments.

Abbreviations.

References.

15 Spectroscopic Imaging with Nanometer Resolution Using Near-Field Methods (Boon-Siang Yeo, Thomas Schmid, Weihua Zhang, and Renato Zenobi.).

15.1 Introduction.

15.2 Methods.

15.3 Applications.

15.4 Current Challenges.

15.5 Summary and Outlook.

Acknowledgments.

References.

Index.