Proteomic and Genomic Analysis of Cardiovascular Disease Book

	Preface
	List of Contributors
Sect. 1	Genomics	1
1	Large Scale Expression Profiling in Cardiovascular Disease Using Microarrays: Prospects and Pitfalls	3
2	Global Genomic Analyses of Cardiovascular Disease: A Potential Map or Blind Alley?	27
3	Heart Failure: A Genomics Approach	45
4	Principles of cDNA Microarrays as Applied in Heart Failure Research	61
5	Gene Profiling in the Heart by Subtractive Hybridization	81
6	DNA Microarray Gene Profiling: A Tool for the Elucidation of Cardioprotective Genes	99
7	Pitfalls Associated with cDNA Microarrays - A Cautionary Tale	113
8	Application of Biologic Skepticism to Analysis of Expression Phenotypes	127
9	Genes Involved in Atherosclerosis and Plaque Formation	141
Sect. 2	Proteomics	153
10	Gene Expression Profiling in Pulmonary and Systemic Vascular Cells Exposed to Biomechanical Stimuli	155
11	Proteomics, a Step Beyond Genomics: Applications to Cardiovascular Disease	173
12	Mass Spectrometry - A Powerful Analytical Tool	195
13	Differential Expression Proteomic Analysis Using Isotope Coded Affinity Tags	213
14	Protein Chip Technology in Proteomics Analysis	235
15	Recent Applications of Functional Proteomics: Investigations in Smooth Muscle Cell Physiology	255
16	Identification of Targets of Phosphorylation in Heart Mitochondria	279
17	Proteomic Characterization of Protein Kinase C Signaling Tasks in the Heart	293
18	Identification of Secreted Oxidative Stress-induced Factors (SOXF) and Associated Proteins: Proteomics in Vascular Biology	307
19	Myofilament Proteomics: Understanding Contractile Dysfunction in Cardiorespiratory Disease	317
Sect. 3	Future Perspectives	339
20	Genomics Perspective for Drug Discovery	341
21	Proteomics: A Post-Genomic Platform for Drug Discovery and Development	359
	Subject Index	391