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Gene Regulation in Eukaryotes Book

Gene Regulation in Eukaryotes
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Gene Regulation in Eukaryotes, A much-needed guide through the overwhelming amount of literature in the field. Comprehensive and detailed, this book combines background information with the most recentinsights. It introduces current concepts, emphasizing the transcriptional control, Gene Regulation in Eukaryotes
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  • Gene Regulation in Eukaryotes
  • Written by author Edgar Wingender
  • Published by Wiley, John & Sons, Incorporated, 1/1/1993
  • A much-needed guide through the overwhelming amount of literature in the field. Comprehensive and detailed, this book combines background information with the most recentinsights. It introduces current concepts, emphasizing the transcriptional control
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1 Control Levels of Gene Expression 1
1.1 Gene Amplification 2
1.2 DNA Rearrangement 5
1.3 DNA Methylation, Chromatin Structure 9
1.4 RNA Spies within Eukaryotic Cells 11
1.5 Transcriptional Regulation 13
1.6 Splicing of RNA 17
1.7 RNA Stability 19
1.8 Translational Control 20
2 The DNA-Dependent RNA Polymerases 23
2.1 Mechanism of Transcription 23
2.2 Target Genes for the Three Polymerases 25
2.3 Structure of RNA Polymerases 25
2.4 Regulation by Phosphorylation 31
2.5 Transcription Termination 32
3 Transcription by RNA Polymerase III and I 35
3.1 The RNA Polymerase III System 36
3.2 The RNA Polymerase I System 54
4 General Transcription Factors of RNA Polymerase II 59
4.1 TFIIA 60
4.2 TFIIB 62
4.3 TFIIE/TFIIF 65
4.4 Eukaryotic General Transcription Initiation Factors and the Bacterial [sigma] Factor 70
4.5 Elongation Factors 72
5 Ubiquitous DNA-Binding Transcription Factors 75
5.1 TATA Box-Binding Factors, TFIID 75
5.2 CCAAT-Binding Factors 85
5.3 The Sp1 Transcription Factor: Useful for Housekeeping 106
5.4 Co-activators 111
6 The C[subscript 2]R[subscript 2] Zinc Finger Structure 115
6.1 Function of Zinc Finger Proteins 115
6.2 Architecture of Zinc Finger Binding to DNA 131
7 The Zinc-Cysteine Cluster in Regulatory Yeast Proteins 141
7.1 GAL4, LAC9 141
7.2 LEU3 and Other Zinc-Cluster Proteins 146
8 Developmental Control by Homeodomain Proteins 151
8.1 The Maturation Genes in Yeast 151
8.2 The Segmentation / Homeotic Gene Products of Drosophila 153
8.3 Homeobox Genes of Vertebrates 167
9 Regulation of Cell Division and Differentiation by Helix-Loop-Helix Proteins 179
9.1 Myc 179
9.2 E12/E47: Immunoglobulin Enhancer-Binding Proteins 184
9.3 The Myogenic Differentiation Factors: MyoD1 and Others 187
9.4 Sensory Organ Development in Drosophila: achaete and acute Gene Product 197
9.5 More Ubiquitous bHLH-ZIP Factors: USF and TFE3 198
9.6 Other HLH Proteins 202
10 Tissue-Specific Gene Regulation by POU-Domain Proteins 205
10.1 The Octamer Transcription Factors 205
10.2 The Pituitary-Specific Gene Regulation by Pit-1/GHF-1 217
10.3 More POU Proteins and their Classification 220
10.4 Liver-Specific Gene Regulation through HNF-1 223
11 Signal Transduction and Gene Regulation 227
11.1 Adenylate Cyclase-Mediated Responses 227
11.2 The Protein Kinase C-Mediated Events 237
11.3 Calcium Ions as Transcription-Regulating Second Messengers 260
11.4 Transcription Activation after Tyrosine Phosphorylation 262
12 The Steroid/Thyroid Hormone Receptor Superfamily 263
12.1 Glucocorticoid, Progesterone and Estrogen Receptors 263
12.2 Thyroid Hormone Receptor t[subscript 3]R / ErbA 295
12.3 Vitamin D[subscript 3] Receptor VDR 302
12.4 Retinoic Acid Receptors RAR 314
12.5 Ecdysone Receptor EcdR 319
12.6 Orphans 320
13 Gene Induction by External Stress: NF-[kappa]B and the Rel Family 321
13.1 Transcription Factor NF-[kappa]B 321
13.2 Induction Mechanisms for NF-[kappa]B 327
13.3 Proteins with NF-[kappa]B-Like Properties 331
13.4 c-Rel Proteins 334
13.5 Paradigm Interferon Gene Regulation and IFN-Induced Genes 335
14 Viral trans-Activators and Tumor Suppressors 341
14.1 SV40 Large Tumor Antigen T-Ag 341
14.2 Adenovirus E1A Protein 345
14.3 Tumor Suppressors 349
References 353
Abbreviations 409
Glossary Index 413
Index 415


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Gene Regulation in Eukaryotes, A much-needed guide through the overwhelming amount of literature in the field.
Comprehensive and detailed, this book combines background information with the most recentinsights. It introduces current concepts, emphasizing the transcriptional control, Gene Regulation in Eukaryotes

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Gene Regulation in Eukaryotes, A much-needed guide through the overwhelming amount of literature in the field.
Comprehensive and detailed, this book combines background information with the most recentinsights. It introduces current concepts, emphasizing the transcriptional control, Gene Regulation in Eukaryotes

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Gene Regulation in Eukaryotes, A much-needed guide through the overwhelming amount of literature in the field.
Comprehensive and detailed, this book combines background information with the most recentinsights. It introduces current concepts, emphasizing the transcriptional control, Gene Regulation in Eukaryotes

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