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Book Categories |
1 | Control Levels of Gene Expression | 1 |
1.1 | Gene Amplification | 2 |
1.2 | DNA Rearrangement | 5 |
1.3 | DNA Methylation, Chromatin Structure | 9 |
1.4 | RNA Spies within Eukaryotic Cells | 11 |
1.5 | Transcriptional Regulation | 13 |
1.6 | Splicing of RNA | 17 |
1.7 | RNA Stability | 19 |
1.8 | Translational Control | 20 |
2 | The DNA-Dependent RNA Polymerases | 23 |
2.1 | Mechanism of Transcription | 23 |
2.2 | Target Genes for the Three Polymerases | 25 |
2.3 | Structure of RNA Polymerases | 25 |
2.4 | Regulation by Phosphorylation | 31 |
2.5 | Transcription Termination | 32 |
3 | Transcription by RNA Polymerase III and I | 35 |
3.1 | The RNA Polymerase III System | 36 |
3.2 | The RNA Polymerase I System | 54 |
4 | General Transcription Factors of RNA Polymerase II | 59 |
4.1 | TFIIA | 60 |
4.2 | TFIIB | 62 |
4.3 | TFIIE/TFIIF | 65 |
4.4 | Eukaryotic General Transcription Initiation Factors and the Bacterial [sigma] Factor | 70 |
4.5 | Elongation Factors | 72 |
5 | Ubiquitous DNA-Binding Transcription Factors | 75 |
5.1 | TATA Box-Binding Factors, TFIID | 75 |
5.2 | CCAAT-Binding Factors | 85 |
5.3 | The Sp1 Transcription Factor: Useful for Housekeeping | 106 |
5.4 | Co-activators | 111 |
6 | The C[subscript 2]R[subscript 2] Zinc Finger Structure | 115 |
6.1 | Function of Zinc Finger Proteins | 115 |
6.2 | Architecture of Zinc Finger Binding to DNA | 131 |
7 | The Zinc-Cysteine Cluster in Regulatory Yeast Proteins | 141 |
7.1 | GAL4, LAC9 | 141 |
7.2 | LEU3 and Other Zinc-Cluster Proteins | 146 |
8 | Developmental Control by Homeodomain Proteins | 151 |
8.1 | The Maturation Genes in Yeast | 151 |
8.2 | The Segmentation / Homeotic Gene Products of Drosophila | 153 |
8.3 | Homeobox Genes of Vertebrates | 167 |
9 | Regulation of Cell Division and Differentiation by Helix-Loop-Helix Proteins | 179 |
9.1 | Myc | 179 |
9.2 | E12/E47: Immunoglobulin Enhancer-Binding Proteins | 184 |
9.3 | The Myogenic Differentiation Factors: MyoD1 and Others | 187 |
9.4 | Sensory Organ Development in Drosophila: achaete and acute Gene Product | 197 |
9.5 | More Ubiquitous bHLH-ZIP Factors: USF and TFE3 | 198 |
9.6 | Other HLH Proteins | 202 |
10 | Tissue-Specific Gene Regulation by POU-Domain Proteins | 205 |
10.1 | The Octamer Transcription Factors | 205 |
10.2 | The Pituitary-Specific Gene Regulation by Pit-1/GHF-1 | 217 |
10.3 | More POU Proteins and their Classification | 220 |
10.4 | Liver-Specific Gene Regulation through HNF-1 | 223 |
11 | Signal Transduction and Gene Regulation | 227 |
11.1 | Adenylate Cyclase-Mediated Responses | 227 |
11.2 | The Protein Kinase C-Mediated Events | 237 |
11.3 | Calcium Ions as Transcription-Regulating Second Messengers | 260 |
11.4 | Transcription Activation after Tyrosine Phosphorylation | 262 |
12 | The Steroid/Thyroid Hormone Receptor Superfamily | 263 |
12.1 | Glucocorticoid, Progesterone and Estrogen Receptors | 263 |
12.2 | Thyroid Hormone Receptor t[subscript 3]R / ErbA | 295 |
12.3 | Vitamin D[subscript 3] Receptor VDR | 302 |
12.4 | Retinoic Acid Receptors RAR | 314 |
12.5 | Ecdysone Receptor EcdR | 319 |
12.6 | Orphans | 320 |
13 | Gene Induction by External Stress: NF-[kappa]B and the Rel Family | 321 |
13.1 | Transcription Factor NF-[kappa]B | 321 |
13.2 | Induction Mechanisms for NF-[kappa]B | 327 |
13.3 | Proteins with NF-[kappa]B-Like Properties | 331 |
13.4 | c-Rel Proteins | 334 |
13.5 | Paradigm Interferon Gene Regulation and IFN-Induced Genes | 335 |
14 | Viral trans-Activators and Tumor Suppressors | 341 |
14.1 | SV40 Large Tumor Antigen T-Ag | 341 |
14.2 | Adenovirus E1A Protein | 345 |
14.3 | Tumor Suppressors | 349 |
References | 353 | |
Abbreviations | 409 | |
Glossary Index | 413 | |
Index | 415 |
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Add Gene Regulation in Eukaryotes, A much-needed guide through the overwhelming amount of literature in the field. Comprehensive and detailed, this book combines background information with the most recentinsights. It introduces current concepts, emphasizing the transcriptional control, Gene Regulation in Eukaryotes to the inventory that you are selling on WonderClubX
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Add Gene Regulation in Eukaryotes, A much-needed guide through the overwhelming amount of literature in the field. Comprehensive and detailed, this book combines background information with the most recentinsights. It introduces current concepts, emphasizing the transcriptional control, Gene Regulation in Eukaryotes to your collection on WonderClub |