Inflammation And Cancer, Vol. 2 Book

Preface v

Contents of Volume I xi

Contributors xv

Part I Crossroads of Inflammation and Cancer: Molecular Aspects

1 Immunohistochemical Analysis of 8-Nitroguanine, A Nitrative DNA Lesion, in Relation to Inflammation-Associated Carcinogenesis Yusuke Hiraku Shosuke Kawanishi 3

2 Molecular Analysis of Genetic Instability Caused by Chronic Inflammation Bin Yan Yuanlin Peng Chuan-Yuan Li 15

3 Obesity Provides a Permissive Milieu in Inflammation-Associated Carcinogenesis: Analysis of Insulin and IGF Pathways Nomeli P. Nunez Stephen D. Hursting Shoshana Yakar Dan Fowler Charles Vinson 29

4 Detecting and Modulating the NF-κB Activity in Human Immune Cells: Generation of Human Cell Lines with Altered Levels of NF-κB Fui G. Goh Helen Banks Irina A. Udalova 39

5 Inflammation-Related Aberrant Patterns of DNA Methylation: Detection and Role in Epigenetic Deregulation of Cancer Cell Transcriptome Hiromu Suzuki Minoru Toyota Yutaka Kondo Yasuhisa Shinomura 55

6 cDNA Microarray Analysis of Inflammatory Breast Cancer Signatures Steven J. Van Laere Peter B. Vermeulen Luc Y. Dirix 71

7 Analysis of the TLR/NF-κB Pathway in Antigen-Presenting Cells in Malignancies Promoted by Inflammation J. Magarian Blander 99

8 Induced Nitric Oxide Synthase as a Major Player in the Oncogenic Transformation of Inflamed Tissue Guang-Yu Yang Sofia Taboada Jie Liao 119

Part II Molecular and Cellular Approaches to Diagnostics and Drug Target Discovery in Inflammation-Related Oncogenesis

9 Development of a Cell-Based Assay to Quantify the Inflammatory Potential of Test Substances and Screen Compound Libraries for Anti-cancer Drug Candidates in a High-Throughput FormatSerguei V. Kozlov 159

10 The NF-κB Transcription Factor Pathway as a Therapeutic Target in Cancer: Methods for Detection of NF-κB Activity Claudio Mauro Francesca Zazzeroni Salvatore Papa Concetta Bubici Guido Franzoso 169

11 Inhibiting Proinflammatory NF-κB Signaling Using Cell-Penetrating NEMO Binding Domain Peptides Lisa A. Madge Michael J. May 209

12 Quantitative Measurement of Cytokine Expression in Synoviocytes Derived from Rheumatoid Arthritis Patients Scott Thomson Irina A. Udalova 233

13 Molecular Characterization of Inflammation-Induced JNK/c-Jun Signaling Pathway in Connection with Tumorigenesis Bozena Kaminska 249

14 Molecular Characterization of STAT Signaling in Inflammation and Tumorigenesis Alicja Adach Aleksandra Ellert-Miklaszewska Bozena Kaminska 265

15 Inflammation and Tumor Progression: A Lesson from TNF-α-Dependent FAK Signaling in Cholangiocarcinoma Naing Naing Mon Toshio Kokuryo Michinari Hamaguchi 279

16 Cyclooxygenase Inhibitors Induce Colon Cancer Cell Apoptosis Via PPARδ → 14-3-3ε Pathway Kenneth K. WuvJun-Yang Liou 295

17 PPARβ/δ Agonist Increases the Expression of PGE<$$$> Receptor Subtype EP4 in Human Lung Carcinoma Cells Jeffrey D. Ritzenthaler Jesse Roman Shou Wei Han 309

18 Investigating Macrophage and Malignant Cell Interactions In Vitro Thorsten Hagemann Toby Lawrence 325

19 Cellular Magnetic Resonance Imaging Using Superparamagnetic Anionic Iron Oxide Nanoparticles: Applications to In Vivo Trafficking of Lymphocytes and Cell-Based Anticancer Therapy Pierre Smirnov 333

20 Application of Phage Display to Discovery of Tumor-Specific Homing Peptides: Developing Strategies for Therapy and Molecular Imaging of Cancer Seung-Min Lee Gil-Suk Yoon Eun-Sang YoovTae-Gyun Kwon In-San Kim Byung-Heon Lee 355

21 Molecular Basis of Histone Deacetylase Inhibitors as New Drugs for the Treatment of Inflammatory Diseases and Cancer Rainer Glauben Britta Siegmund 365

22 Peptide YY Mediates Inhibition of Tumor Growth and Inflammation Julie A. Alosi David W. McFadden 377

Index 395