Disease Markers in Exhaled Breath: Basic Mechanisms and Clinical Applications, Vol. 346 Book

	Preface
	Sponsors
	List of Participants
Pt. I	Introduction to Disease Markers in Exhaled Breath
Sect. 1	Nitric Oxide
	Regulation of Nitric Oxide Synthases in the Lung	3
	Nitric Oxide Production in the Lung and its Regulation by Oxygen	11
	S-Nitrosothiols in Respiratory Biology	18
	Inhibitors of Nitric Oxide Synthase: Experimental Findings and Clinical Implications	24
	Inhaled NO as a Replacement Therapy	30
	Physiology of Exhaled Nitric Oxide	35
	The "Vascular" Origins of Exhaled Nitric Oxide	49
	Exhaled NO originates in Airway Epithelium	52
	NO is Generated via NOS Enzymes	57
	Technical Aspects of Exhaled NO: Investigator Point of View	62
	Technical Aspects of Exhaled Nitric Oxide: Aerocrine Point of View	64
Sect. 2	Carbon Monoxide
	Cytoprotection by Heme Oxygenase / CO in the Lung	73
	Role of Heme Oxygenase in Airway Smooth Muscle Contractility	79
	Exhaled Carbon Monoxide is Produced in the Lungs	84
	Exhaled Carbon Monoxide is Delivered from Systemic Sources	88
	Kinetics of Carbon Monoxide Accumulation in Exhaled Breath	93
	ETCOc: An Indicator of Hemolysis in Neonatal Hyperbilirubinemia	96
Sect. 3	Volatile Organic Compounds (VOCs)
	Volatile Organic Compounds as Exposure Markers	105
	Volatile Organic Compounds as Markers in Normal and Diseased States	113
Sect. 4	The "Living State"
	The Living State: Intimate Insights through Personal Discoveries	125
Pt. II	Asthma
	Biology of Asthma	133
	Transcriptional Regulation of Airway Inflammation	143
	Molecular Mechanisms of Steroid Actions	151
	Nitric Oxide Reactions in the Asthmatic Airway	159
	Regulation of pH in the Human Airway: Mechanisms and Monitoring	167
	Markers in Exhaled Air and Condensate to Monitor Treatment in Asthma	177
	Extended NO Analysis Applied to Patients with Known Altered Values of Exhaled NO	187
	Exhaled Nitric Oxide and Atopy	191
	Bradykinin and Exhaled Nitric Oxide in Asthma	196
	Exhaled NO is an Optimal Marker of Severity and Responsiveness to Therapy in Asthma	199
	Superoxide-NO Interactions in Paranasal Sinus Inflammatory Diseases	202
Pt. III	Chronic Lung Diseases
	Biology, Diagnosis and Management of COPD	209
	Disease Markers in COPD: Exhaled Breath vs. Exhaled Condensate	218
	The Biology of Cystic Fibrosis	223
	Exhaled Markers in Cystic Fibrosis	234
	Lung Cancer Screening by Breath Analysis	242
	Nitric Oxide and Rheumatic Diseases	246
	Nitric Oxide in Hepatopulmonary Syndrome	257
	Pathological Changes in the Airways Epithelium of Liquidators of the Chernobyl Catastrophe	261
Pt. IV	Transplantation
	Heme Oxygenase-1 and/or Carbon Monoxide can Promote Organ Graft Survival	267
	Mechanisms of and Clinical Efforts to Minimise Perioperative Lung Injury	274
	Condensate Inflammatory Markers in Lung Transplantation	284
	Exhaled Nitric Oxide (NO) in Human Lung Ischemia-Reperfusion	291
	In Situ Lung Autotransplantation Model in Pigs	300
	Pathogenetic Mechanisms Leading to Obliterative Bronchiolitis	304
Pt. V	ARDS and Oxidative Stress
	Clinical Pathology of ARDS	319
	Markers of Oxidative Stress in Exhaled Breath Condensate	333
	Volatile Organic Compounds as Prognostic Markers in ARDS	338
	Do Reactive Oxygen-Nitrogen Intermediates Contribute to the Pathogenesis of ARDS?	344
	Modulation of Active Alveolar Na[superscript +] Transport by Reactive Oxygen-Nitrogen Intermediates	354
	Luteolin Reduces LPS-Induced TNF-[alpha] Production and Protects Mice against LPS Toxicity	366
	Acute Lung Injury in the Setting of Cardiopulmonary Bypass	369
	Oxidative Stress During Cardiac Surgery in Diabetic Patients	375
Pt. VI	New Technological Developments
	Exhaled Breath Condensate	383
	Smell as a Diagnostic Tool in the 21st Century: The Portable Electronic Nose	387
	Biosensors and Express Biochemical Diagnostics of Some Diseases	391
	Infrared Laser Spectrometer for Real-Time Analysis of Ethane in Exhaled Human Breath	395
	Methods of Tuneable Diode Laser Absorption Spectroscopy Applied to the Analysis of Exhaled Breath	400
Pt. VII	Industrial Forum
	Industrial Forum - Aerocrine AB	407
	Biochemical Diagnostics of the Lung with ECoScreen	410
	Portability and Flexibility in Exhaled Breath Condensate Collection	413
	Author Index	417