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The 2nd Conference on Skeletal Medicine and Biology: Overview and Some Comments Mone Zaidi xi
Intracellular Protein Degradation From a Vague Idea through the Lysosome and the Ubiquitin-Proteasome System and on to Human Diseases and Drug Targeting: Nobel Lecture, December 8, 2004 Aaron Ciechanover 1
Part I New Insights into Bone Development
Multiplicity of BMP Signaling in Skeletal Development Xiangwei Wu Weibin Shi Xu Cao 29
Nephroblastoma Overexpressed (Nov) Is a Novel Bone Morphogenetic Protein Antagonist Ernesto Canalis 50
The Role of the Perichondrium in Fetal Bone Development Henry M. Kronenberg 59
The Pthrp Functional Domain Is at the Gates of Endochondral Bones Arthur E. Broadus Carolyn Macica Xuesong Chen 65
Axin 1 and Axin 2 Are Regulated by TGF-β and Mediate Cross-talk between TGF-β and Wnt Signaling Pathways Debbie Y. Dao Xue Yang Di Chen Michael Zuscik Regis J. O'Keefe 82
Synovial Joint Formation during Mouse Limb Skeletogenesis: Roles of Indian Hedgehog Signaling Eiki Koyama Takanaga Ochiai Ryan B. Rountree David M. Kingsley Motomi Enomoto-Iwamoto Masahiro Iwamoto Maurizio Pacifici 100
Morphogen Receptor Genes and Metamorphogenes: Skeleton Keys to Metamorphosis Frederick S. Kaplan Jay Groppe Robert J. Pignolo Eileen M. Shore 113
Differential Effects of Vascular Endothelial Growth Factor on Joint Formation During Limb Development Gloria Emeli Cortina-Ramirez Jesus Chimal-Monroy 134
Negative Regulation of Otic Capsule Chondrogenesis: It Can Make You Smad Wei Liu Sydney Butts Harold Kim Dorothy A. Frenz 141
A Novel Transgenic Mouse Model to Study the Osteoblast Lineage In Vivo Christa Maes Tatsuya Kobayashi Henry M.Kronenberg 149
Part II Formation, Function, and Fate of Bone Cells
Balanced Regulation of Proliferation, Growth, Differentiation, and Degradation in Skeletal Cells Harry C. Blair Li Sun Ronald A. Kohanski 165
Control of Postnatal Bone Mass by the Zinc Finger Adapter Protein Schnurri-3 Laurie H. Glimcher Dallas C. Jones Marc N. Wein 174
Suppression of PPAR Transactivation Switches Cell Fate of Bone Marrow Stem Cells from Adipocytes into Osteoblasts Ichiro Takada Miyuki Suzawa Kunihiro Matsumoto Shigeaki Kato 182
Transcriptional Regulation of Osteoblasts Renny T. Franceschi Chunxi Ge Guozhi Xiao Hernan Roca Di Jiang 196
Identification of Additional Dimerization Partners of FIAT, the Factor Inhibiting ATF4-Mediated Transcription Rene St-Arnaud Bilal Elchaarani 208
Cellular and Molecular Consequences of Calcineurin Aα Gene Deletion Li Sun, Ling-Ling Zhu Neeha Zaidi Guozhe Yang Baljit S. Moonga Etsuko Abe Jameel Iqbal Solomon Epstein Harry C. Blair Christopher L. -H. Huang Mone Zaidi 216
The Role of NFAT in Osteoclast Formation Hiroshi Takayanagi 227
Mechanisms of Osteoclastic Secretion Haibo Zhao F. Patrick Ross 238
New Roles for Osteoclasts in Bone Brendan F. Boyce Zhenqiang Yao Qian Zhang Roulin Guo Yan Lu Edward M. Schwarz Lianping Xing 245
Similarities and Contrasts in Ryanodine Receptor Localization and Function in Osteoclasts and Striated Muscle Cells Christopher L. -H. Huang Li, Sun James A. Fraser Andrew A. Grace Mone Zaidi 255
Posttranslational Regulation of Bim by Caspase-3 Hidetoshi Wakleyama Toru Akiyama Yuho Kadono Masaki Nakamura Yasushi Oshima Kozo Nakamura Sakae Tanaka 271
Osteocytes as Dynamic Multifunctional Cells Lynda F. Bonewald 281
A Chromosomal Inversion within a Quantitative Trait Locus Has a Major Effect on Adipogenesis and Osteoblastogenesis Cheryl L. Ackert-Bicknell Jesse L. Salisbury Mark Horowitz Victoria E. DeMambro Lindsay G. Horton Kathryn L. Shultz Beata Lecka-Czernik Clifford J. Rosen 291
Osteoblasts Cultured on Three-Dimensional Synthetic Hydroxyapatite Implanted on a Chick Allantochorial Membrane Induce Ectopic Bone Marrow Differentiation Lucia Mancini Roberto Tamma Maria Settanni Claudia Camerino Nicola Patano Giovanni Greco|cMaurizio Strippoli Alberta Zallone 306
Trail Is Involved in Human Osteoclast Apoptosis Giacomina Brunetti Angela Oranger Giorgio Mori Roberto Tamma Adriana Di Benedetto Paolo Pignataro Felice R. Grassi Alberta Zallone Maria Grano Silvia Colucci 316
Proteomic Analysis of Hydroxyapatite Interaction Proteins in Bone Hai-Yan Zhou 323
Part III Regulation of Skeletal Remodeling
Nuclear Receptors and Bone Ronald N. Margolis 327
Glucocorticoids and the Osteoclast Hyun-Ju Kim Haibo Zhao Hideki Kitaura Sandip Bhattacharyya Judson A. Brewer Louis J. Muglia F. Patrick Ross Steven L. Teitelbaum 335
Vitamin D: Molecular Mechanism of Action Sylvia Christakos Puneet Dhawan Bryan Benn Angela Porta Matthias Hediger Goo T. Oh Eui-Bae Jeung Yan Zhong Dare Ajibade Kopal Dhawan Sneha Joshi 340
Parathyroid Hormone Regulates Histone Deacetylases in Osteoblasts Emi Shimizu Nagarajan Selvamurugan Jennifer J. Westendorf Nicola C. Partridge 349
Parathyroid Hormone Stimulation of Noncanonical Wnt Signaling in Bone Marika K. Bergenstock Nicola C. Partridge 354
T Cells: Unexpected Players in the Bone Loss Induced by Estrogen Deficiency and in Basal Bone Homeostasis M. Neale Weitzmann Roberto Pacifici 360
Proresorptive Actions of FSH and Bone Loss Mone Zaidi Harry C. Blair Jameel Iqbal Ling Ling Zhu T. Rajendra Kumar Alberta Zallone Li Sun 376
Bone Loss in Thyroid Disease: Role of Low TSH and High Thyroid Hormone Etsuko Abe Li Sun Jeffrey Mechanick Jameel Iqbal Kosj Yamoah Ramkumarie Baliram Ario Arabi Baljit S. Moonga Terry F. Davies Mone Zaidi 383
Hematopoietic Stem Cell Trafficking: Regulated Adhesion and Attraction to Bone Marrow Microenvironment Simon Mendez-Ferrer Paul S. Frenette 392
Regulation of Skeletal Remodeling by the Endocannabinoid System Itai A. Bab 414
Androgens Promote Preosteoblast Differentiation via Activation of the Canonical Wnt Signaling Pathway Xin-Hua Liu Alexander Kirschenbaum Shen Yao Alice C. Levine 423
Tumor Necrosis Factor Family Receptors Regulating Bone Turnover: New Observations in Osteoblastic and Osteoclastic Cell Lines Lisa J. Robinson Christopher W. Borysenko Harry C. Blair 432
Bone Loss After Temporarily Induced Muscle Paralysis by Botox Is Not Fully Recovered After 12 Weeks Susan K. Grimston Matthew J. Silva Roberto Civitelli 444
Genetics of Hypercalciuric Nephrolithiasis: Renal Stone Disease Michael J. Stechman Nellie Y. Loh Rajesh V. Thakker 461
Correlation among Hyperphosphatemia, Type II Sodium-Phosphate Transporter Activity, and Vitamin D Metabolism in Fgf-23 Null Mice Despina Sitara 485
Osteoblast and Osteoclast Differentiation in Modeled Microgravity Ritu Saxena George Pan Jay M. McDonald 494
Evolution, Aging, and Osteoporosis Stephanie Tung Jameel Iqbal 499
Index of Contributors 507
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Amanda Urban
reviewed Skeletal Biology and Medicine: Aspects of Bone Morphogenesis and Remodeling on March 24, 2017
Skeletal Biology and Medicine
[
The good:
- bold theorizing! But testable and falsifiable, so it has more merit than technically savvy sci-fi. (still, all it changes is the mechanism. It doesn't address the selection pressures, why intelligence, or many of the objections he raises to a darwinian account)
- many important and fascinating experiments are described
- even if you don't buy his theory you will learn a lot of interesting facts about genetics and epigenetics, the technical level is high and, especially in the last couple of parts, very satisfying.
- Fills a niche, not a lot of interesting material on the subject that's available to the general reader.
The bad:
- didn't make it clear to me why his evolutionary stories were more plausible and useful than all the ones he dismisses (even tho I find his exercises in making alternate accounts pedagogically useful)
- Apparently the discovery of fire and heat-preparation of food was not an event worth mentioning, even tho this is interpreted as causing the shortening of our intestines which lead to much better energy utilization (the intestines need a lot of energy to do their work), freeing up resources for a power-hungry organ like the brain
- although he did make a point of the importance of brain plasticity, he never really addresses the long developmental time of human children and the extent of dendritic pruning that takes place during this period. Having a longer window for critical and sensitive periods sounds like an important factor in how much culture can change an organism.
- his discussion of how traits like intelligence or musicality (or indeed a brain region specific to written language) was useless to our pre-historic forefathers wasn't entirely convincing (what good is a cubic-root to a caveman? I'm not sure, but pattern recognition and being able to think and manipulate abstractions in some capacity sounds like it could be useful? It does sound like it's a subject that has been covered by others, so I should perhaps not hold it against him for not dedicating more time to the subject). (hide spoiler)]
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Add Skeletal Biology and Medicine: Aspects of Bone Morphogenesis and Remodeling, This volume highlights new insights into the mechanisms of bone development, including cellular and mechanical factors, receptors, and signaling pathways and their role in both normative and pathologic states of bone. The first of two volumes, the volu, Skeletal Biology and Medicine: Aspects of Bone Morphogenesis and Remodeling to the inventory that you are selling on WonderClubX
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Add Skeletal Biology and Medicine: Aspects of Bone Morphogenesis and Remodeling, This volume highlights new insights into the mechanisms of bone development, including cellular and mechanical factors, receptors, and signaling pathways and their role in both normative and pathologic states of bone. The first of two volumes, the volu, Skeletal Biology and Medicine: Aspects of Bone Morphogenesis and Remodeling to your collection on WonderClub |