Quinolone Antimicrobial Agents Book

	Contributors
	Preface
	Introduction
I	Mechanisms and Spectrum of Antibacterial Activity and Resistance
1	Structure-Activity Relationships of the Quinolone Antibacterials in the New Millennium: Some Things Change and Some Do Not	3
2	Mechanisms of Quinolone Action	19
3	Mechanisms of Quinolone Resistance	41
4	Quinolones and Eukaryotic Topoisomerases	69
5	Activity In Vitro of the Quinolones	91
II	Pharmacology
6	Pharmacokinetics of Fluoroquinolones	115
7	Drug-Drug Interactions	133
8	Pharmacodynamics of Quinolone Antimicrobial Agents	147
III	Clinical Applications
9	Treatment of Urinary Tract Infections	159
10	Use of Quinolones for Treatment of Sexually Transmitted Diseases	171
11	Treatment and Prophylaxis of Gastroenteritis	193
12	Treatment of Intra-Abdominal Infections	217
13	Treatment of Community-Acquired Respiratory Tract Infections	227
14	Treatment of Infections of the Ears, Nose, and Throat and Nasal Carriage	245
15	Treatment of Osteomyelitis and Septic Arthritis	251
16	Treatment of Experimental and Human Bacterial Endocarditis with Quinolone Antimicrobial Agents	259
17	Treatment of Bacterial Meningitis and Other Central Nervous Systems Infections	275
18	Treatment of Eye Infections	291
19	Treatment of Skin and Soft Tissue Infections	311
20	Treatment of Intracellular Infections	323
21	Fluoroquinolones in Intensive Care Unit Infections	337
22	Quinolones in Pediatrics	343
23	Quinolone Resistance and Its Clinical Relevance	355
24	Veterinary Use of Quinolones and Impact on Human Infections	387
IV	Adverse and Other Effects
25	Adverse Effects	407
26	QT Prolongation with Quinolone Antimicrobial Agents	421
27	Effects on Connective Tissue Structures	441
28	Phototoxicity Due to Fluoroquinolones	451
29	Central Nervous System Toxicity	461
30	Effects of Quinolones on the Immune System	467
	Index	475