Molecular Pathogenesis of Periodontal Disease Book

	Contributors
	Preface
	Acknowledgments
	Introduction
1	Epidemiology of Subgingival Bacterial Pathogens in Periodontal Disease	3
2	Porphyromonas gingivalis Fimbriae: Structure, Function, and Insertional Inactivation Mutants	13
3	Molecular Genetic Approaches for Identifying Virulence Factors of Porphyromonas gingivalis	25
4	DNA Fingerprinting of Porphyromonas gingivalis by Arbitrarily Primed PCR	33
5	Relationship between Iron Availability and Periodontal Disease Associated with Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans	47
6	Invasion of Cultured Epithelial Cells by Periodontopathogens	57
7	Molecular Biology of Actinobacillus actinomycetemcomitans Leukotoxin	69
8	Bacterial Polysaccharides as Microbial Virulence Factors	83
9	Campylobacter rectus Toxins	93
10	Bacterial Endotoxic Substances and Their Effects on Host Cells	105
11	CD14 and Lipopolysaccharide Binding Protein Control Host Responses to Bacterial Lipopolysaccharide
12	Cytokine Networks and Immunoglobulin Synthesis in Inflamed Gingival Tissues	135
13	Modulatory Role of T Lymphocytes in Periodontal Inflammation	147
14	Human Immune Responses in Periodontal Disease: Analysis of Severe Combined Immunodeficient Mice Reconstituted with Lymphocytes from Patients with Localized Juvenile Periodontitis	159
15	Mechanisms of Regulation of Bone Formation by Proinflammatory Cytokines	171
16	Regulation of Chronic Inflammation	183
17	Host-Mediated Extracellular Matrix Destruction by Metalloproteinases	191
18	Role of Prostaglandins in High-Risk Periodontitis Patients	203
19	Leukocyte Adhesion Molecules CD11/CD18 and Their Role in Periodontal Diseases	215
20	Role of the Extracellular Matrix in Inflammation	235
21	The Platelet as an Inflammatory Cell in Periodontal Diseases: Interactions with Porphyromonas gingivalis	247
22	Role of Antibodies in Periodontopathic Bacterial Infections	257
23	Immunization with Porphyromonas gingivalis Fimbriae and a Synthetic Fimbrial Peptide	267
24	T-Cell and B-Cell Epitope Mapping and Construction of Peptide Vaccines	279
25	Regulation of Immunoglobulin A Responses for Oral Mucosal Immunity
26	New Ideas about Neutrophil Antimicrobial Mechanisms: Antibiotic Peptides, Postphagocytic Protein Processing, and Cystosolic Defense Factors	321
27	Antimicrobial Dysfunction in Localized Juvenile Periodontitis Neutrophils	337
28	Neutrophil Receptors: N-Formyl-l-Methionyl-l-Leucyl-l-Phenylalanine and Interleukin-8	351
29	The OmpA Protein of Actinobacillus actinomycetemcomitans: Physicochemical and Immunologic Features	363
30	Genetics of Early-Onset Periodontal Diseases	373
31	Principles of Regenerative Therapy	393
32	Differential Regulation of Periodontal Ligament Cell Activities by Platelet-Derived Growth Factor, Insulin-Like Growth Factor I, and Epidermal Growth Factor	403
33	Polypeptide Growth Factors: Molecular Mediators of Tissue Repair	415
34	Role of Osteogenic (Bone Morphogenetic) Protein and Platelet-Derived Growth Factor in Periodontal Wound Healing	427
35	Extracellular Matrix and Bone Morphogenetic Proteins: Molecular Approaches to Dentin and Periodontal Repair	439
	Index	449