Basic Mechanisms of Pediatric Respiratory Disease Book

	Preface to the Second Edition
	Preface to the First Edition
	Foreword
I	Genetic and Developmental Biology of the Respiratory System
1	Approach to Pulmonary Diseases with a Genetic Basis	1
2	Genetic and Molecular Basis of Airway and Lung Development	9
3	Genetics of Lung Disease: Surfactant Protein B Deficiency	24
4	Developmental Biology of Surfactant	37
II	Structure-Function Relations of the Respiratory System During Development
5	Mechanisms of Lung Vascular Development	49
6	Tissue Interactions in Lung Organogenesis	68
7	Prenatal and Postnatal Development of the Pulmonary Circulation	77
8	Responses of the Developing Lung to Injury	102
9	Development of the Thoracic Cage	124
10	Structural and Functional Development of Respiratory Muscle	139
III	Developmental Physiology of the Respiratory System
11	Respiratory Function in Infants	154
12	Comparative Aspects of Neonatal Respiratory Mechanics	171
13	Physiology of Cough	179
14	Oxygen Transport	184
15	Pulmonary Gas Exchange	200
16	Tissue and Cellular Carbon Dioxide Transport and Acid-Base Balance	216
17	Heart-Lung Interactions	234
18	Respiratory Muscle Function: Implications for Ventilatory Failure	250
19	Airway Smooth Muscle	261
20	Pulmonary Edema and Injury to the Developing Lung	272
21	Ion Flux and Homeostasis in the Lung	285
22	Disorders of Ion Transport	294
23	Cellular and Molecular Mechanisms in Hypoxic Injury or Adaptation	312
24	Effects of Hypoxia on the Developing Pulmonary Circulation	328
25	Regulation of Cerebral Vascular Function by Oxygen	345
26	Cardiopulmonary Physiology at Altitude	356
27	Laryngeal Function and Respiratory System Neural Reflexes	377
28	Fetal Respiratory Control and Changes at Birth	386
29	Postnatal Development of Respiratory Control	398
30	Sleep and Respiratory Control	412
31	Interacting Mechanisms of Physical Activity and Growth in Children	431
IV	Inflammation and Pulmonary Defense Mechanisms
32	Ciliary Abnormalities	445
33	Ciliogenesis of Airway Epithelium	452
34	Immunology and Cellular Defense Mechanisms in the Lung	465
35	Airway Secretions	472
36	Pulmonary Macrophages: Origins, Functions, and Clearance	489
37	The Role of Oxidant Injury in the Pathogenesis of Bronchopulmonary Dysplasia	505
38	Virus-Induced Inflammation in Airways	518
39	Fibroproliferative Response: Molecular Mediators and Pathophysiologic Relevance	528
	Index	537