Angiotensin II Receptor Blockade Physiological and Clinical Implications Book

	Contributing Authors
	Dedication
	Preface
	Acknowledgments
1	Pharmacological Interruption of the Renin System and the Kidney: Lessons from Comparative Pharmacology	3
2	The Brain Renin-Angiotensin System and Salt-Sensitive Hypertension	15
3	AT[subscript 1] Angiotensin Receptor Blockade and Angiotensin-Converting Enzyme Inhibition: Effects on Vascular Remodeling and Endothelial Dysfunction in SHR	33
4	Cellular Physiology of Angiotensin II Receptors in Vascular Smooth Muscle Cells	41
5	Angiotensin II Enhanced the Expression of Inhibitory Guanine Nucleotide Regulatory Protein in Vascular Smooth Muscle Cells: Blockade by AT[subscript 1] Antagonist	51
6	Comparison of the Inhibitory Actions of Angiotensin AT[subscript 1] Receptor Antagonists in the Peripheral Vascular Bed	65
7	Angiotensin II Receptor Antagonists in Patients with Renal Failure and on Hemodialysis	87
8	The Place of Angiotensin II Antagonists in Relation to the Canadian Hypertension Society Guidelines	93
9	Translating Clinical Guidelines for Management of Heart Failure and Hypertension into Clinical Practice	105
10	Cough Induced by Pharmacological Modulation of the Renin-Angiotensin-Aldosterone System. Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Antagonists	115
11	Angiotensin II Receptors AT[subscript 1] and AT[subscript 2]: New Mechanisms of Signaling and Antagonistic Effects of AT[subscript 1] and AT[subscript 2]	129
12	Angiotensin Receptor Antagonists and Cardiovascular Remodeling	141
13	Intersubject Variability in the Pharmacokinetics of Losartan	153
14	Functional Analysis of Tissue Renin-Angiotensin System Using "Gain and Loss of Function" Approaches: In vivo Test of in vitro Hypothesis	163
15	Exploring the Difference Between Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Antagonists. A Focus on Bradykinin	175
16	Role of Cytokines in Septic Cardiomyopathy	185
17	In Pursuit of Optimal Care and Outcomes for Patients with Congestive Heart Failure: Insights from the Past Decade	221
18	Atherosclerosis: Implications of Angiotensin II and the AT-1 Receptor	233
19	Influence of AT[subscript 1] Receptor Inhibition on Cardiac Function and Structure of Diabetic Rats	245
20	Role of Myocardial Tissue Angiotensin (Ang.) II in Cardiac Pathology	261
21	Mechanical Stress, Local Renin-Angiotensin System and Cardiac Hypertrophy. An Overview	269
22	Role of Renin-Angiotensin System in Cardiac Hypertrophy and Failure	283
23	Effect of Angiotensin-Converting Enzyme Inhibition and of Angiotensin II Receptor Blockade on the Development of Cardiac Hypertrophy in Rats	311
24	Effects of Inhibition of Angiotensin-Converting Enzyme on Myocardial and Myocyte Remodeling in Chronic Volume Overload-Induced Cardiac Hypertrophy in the Dog	323
25	The Site of Angiotensin Generation: Focus on the Heart	345
26	Angiotensin II-Mediated STAT Signal Transduction: Studies in Neonatal Rat Cardiac Fibroblasts and CHO-K1 Cells Expressing AT[subscript 1A] Receptors	357
27	Cardiac Angiotensin II Subtype 2 Receptor Signal Transduction Pathways: Embryonic Cardiomyocytes and Human Heart	367
28	Angiotensin II Stimulates Contractility and C-fos Gene Expression in Isolated Atrial Human Myocardium	385
29	Stimulation of the Na[superscript +]/Ca[superscript 2+] Exchanger by Angiotensin II	395
30	Developmental Regulation of the Cardiac Renin-Angiotensin System: Expression and Association with Growth and Apoptosis	403
31	Angiotensin II-Regulated Apoptosis in Cardiovascular Remodeling	415
32	The Role of Angiotensin II in Stretch-Activated Signal Transduction of the Normal, Hypertrophied, and Failing Adult Heart	423
33	Role of Angiotensin II Receptor Blockade During Remodeling After Myocardial Infarction	437
34	Local Angiotensin II and Tissue Repair Post-Myocardial Infarction	451
35	Losartan Pretreatment Inhibits an Early Activation of Matrix Metalloproteinases in Acute Myocardial Infarction	459
36	The Role of Angiotensin II in Post-Translational Regulation of Fibrillar Collagens in Fibrosed and Failing Rat Heart	471
37	Characteristics and Mechanisms of Angiotensin II-Related Myocardial Damage	499
38	Comparison of Direct Angiotensin II Receptor Blockade with Converting Enzyme Inhibition in the Rat Model of Heart Failure	515
39	Effects of Captopril on Myocardial Oxidative Stress Changes in Post-MI Rats	527
40	Role of Angiotensin in Angiogenesis and Cardiac Fibrosis in Heart Failure	537
41	Role of Angiotensin II in Myocardial Ischemia/Reperfusion Injury	551
42	Effects of Angiotensin II Receptor Antagonist on Cardiac Remodeling in Cardiomyopathic Hamster Hearts	561
	Index	571