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Blood Substitutes: Physiological Basis of Efficacy Book

Blood Substitutes: Physiological Basis of Efficacy
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Blood Substitutes: Physiological Basis of Efficacy, The development of a substitute for transfused red blood cells is a highly sought-after goal. Such products potentially would be safer than human (allogeneic) blood because they would eliminate the possibility of transmitting infectious agents such as HIV, Blood Substitutes: Physiological Basis of Efficacy
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  • Blood Substitutes: Physiological Basis of Efficacy
  • Written by author Robert M. Winslow
  • Published by Birkhauser Verlag, 7/31/2012
  • The development of a substitute for transfused red blood cells is a highly sought-after goal. Such products potentially would be safer than human (allogeneic) blood because they would eliminate the possibility of transmitting infectious agents such as HIV
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Authors

Foreword
Preface
Ch. 1 Transfusion Alternatives: Impact on Blood Banking Worldwide 1
Ch. 2 Demonstration of the Efficacy of a Therapeutic Agent 20
Ch. 3 A Physiologic Basis for the Transfusion Trigger 25
Ch. 4 Combat Casualties, Blood and Red Blood Cell Substitutes: A Military Perspective 42
Ch. 5 Clinical Development of Perfluorocarbon-based Emulsions as Red Cell Substitutes 53
Ch. 6 Design of Chemically Modified and Recombinant Hemoglobins as Potential Red Cell Substitutes 76
Ch. 7 Encapsulation of Hemoglobin in Liposomes 90
Ch. 8 Stability and Toxicity of Hemoglobin Solutions 105
Ch. 9 Red Cell Substitutes in the Kidney 132
Ch. 10 A Theoretical Analysis of Oxygen Transport: A New Strategy for the Design of Hemoglobin-based Red Cell Substitutes 143
Ch. 11 Microcirculatory Consequences of Blood Substitution with [alpha][alpha]-Hemoglobin 155
Ch. 12 Oxygen Delivery Regulation: Implications for Blood Substitutes 175
Ch. 13 Tumor Oxygenation and Radiosensitivity 187
Index 200


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Blood Substitutes: Physiological Basis of Efficacy, The development of a substitute for transfused red blood cells is a highly sought-after goal. Such products potentially would be safer than human (allogeneic) blood because they would eliminate the possibility of transmitting infectious agents such as HIV, Blood Substitutes: Physiological Basis of Efficacy

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Blood Substitutes: Physiological Basis of Efficacy, The development of a substitute for transfused red blood cells is a highly sought-after goal. Such products potentially would be safer than human (allogeneic) blood because they would eliminate the possibility of transmitting infectious agents such as HIV, Blood Substitutes: Physiological Basis of Efficacy

Blood Substitutes: Physiological Basis of Efficacy

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Blood Substitutes: Physiological Basis of Efficacy, The development of a substitute for transfused red blood cells is a highly sought-after goal. Such products potentially would be safer than human (allogeneic) blood because they would eliminate the possibility of transmitting infectious agents such as HIV, Blood Substitutes: Physiological Basis of Efficacy

Blood Substitutes: Physiological Basis of Efficacy

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