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Preface v
Contributors xi
Using Modified-Release Formulations to Maintain and Develop Markets
The Modified-Release Drug Delivery Landscape: The Commercial Perspective Stephen Perrett 1
The Modified-Release Drug Delivery Landscape: Academic Viewpoint Juergen Siepmann Florence Siepmann 17
The Modified-Release Drug Delivery Landscape: Advantages and Issues for Physicians and Patients Marco M. Anelli 35
The Modified-Release Drug Delivery Landscape: Drug Delivery Commercialization Strategies Fintan Walton 49
Ocular Technologies
Ophthalmic Drug Delivery Pascal Furrer Florence Delie Bernard Plazonnet 59
Intraocular Implants for Controlled Drug Delivery Leila Bossy Signe Erickson Robert Gurny Florence Delie 85
Bioadhesive Ophthalmic Drug Inserts (BODI) for Veterinary Use Pascal Furrer Olivia Felt Robert Gurny 101
Ion Exchange Resin Technology for Ophthalmic Applications Rajni Jani Erin Rhone 109
Injection and Implant Technologies
Injections and Implants Majella E. Lane Franklin W. Okumu Palani Balausubramanian 123
Long-Acting Protein Formulation-PLAD Technology Franklin W. Okumu 133
Long-Term Controlled Delivery of Therapeutic Agents by the Osmotically Driven DUROS Implant Jeremy C. Wright John Culwell 143
The SABER Delivery System for Parenteral Administration Jeremy C. Wright A. Neil Verity Franklin W. Okumu 151
Improving the Delivery of Complex Formulations Using the DepotOne Needle Kevin Maynard Peter Crocker 159
ReGel Depot Technology Ramesh C. Rathi Kirk D. Fowers 171
The Atrigel Drug Delivery System Eric J. Dadey 183
Enhancing Drug Delivery by Chemical Modification Mimoun Ayoub Christina Wedemeyer Torsten Wohr 191
DepoFoam Multivesicular Liposomes for the Sustained Release of Macromolecules William J. Lambert Kathy Los 207
ALZAMER Depot Bioerodible Polymer Technology Guohua Chen Gunjan Junnarkar 215
Pegylated Liposome Delivery of Chemotherapeutic Agents: Rationale and Clinical Benefit Francis J. Martin 227
Dermal and Transdermal Technologies
Dermal and Transdermal Drug Delivery Jonathan Hadgraft Majella E. Lane Adam C. Watkinson 263
ALZA Transdermal Drug Delivery Technologies Rama Padmanabhan J. Bradley Phipps Michel Cormier Janet Tamada Jay Audett J. Richard Gyory Peter E. Daddona 273
Microneedles for Drug Delivery Mark R. Prausnitz Harvinder S. Gill Jung-Hwan Park 295
Transfersome: Self-Optimizing and Self-Driven Drug-Carrier, for Localized and Transdermal Drug Delivery Gregor Cevc 311
Advances in Wound Healing Michael Walker Steven Percival 325
Ultrasound-Mediated Transdermal Drug Delivery Samir Mitragotri Joseph Kost 339
Lipid Nanoparticles with Solid Matrix for Dermal Delivery: Solid Lipid Nanoparticles and Nanostructured Lipid Carriers Eliana B. Souto Rolf D. Petersen Rainer H. Muller 349
LidoSite-Vyteris Iontophoretic Technology Lakshmi Raghavan Ashutosh Sharma 373
Nail Delivery Darren M. Green Keith R. Brain Kenneth A. Walters 383
Immediate Topical Drug Delivery Using Natural Nano-Injectors Tamar Lotan 395
DOT Matrix Technology Juan A. Mantelle 405
The PassPort System: A New Transdermal Patch for Water-Soluble Drugs, Proteins, and Carbohydrates Alan Smith Eric Tomlinson 417
Nasal Technologies
Nasal Drug Delivery Pradeep K. Karla Deep Kwatra Ripal Gaudana Ashim K. Mitra 427
Controlled Particle Dispersion: A Twenty-First-Century Nasal Drug Delivery Platform Marc Giroux Peter Hwang Ajay Prasad 451
DirectHaler Nasal: Innovative Device and Delivery Method Troels Keldmann 469
Vaginal Technologies
Intravaginal Drug Delivery Technologies A. David Woolfson 481
Vaginal Rings for Controlled-Release Drug Delivery R. Karl Malcolm 499
Phospholipids as Carriers for Vaginal Drug Delivery Mathew Leigh 511
SITE RELEASE, Vaginal Bioadhesive System Jennifer Gudeman Daniel J. Thompson R. Saul Levinson 521
Clindamycin Vaginal Insert Janet A. Halliday Steve Robertson 531
Bioresponsive Vaginal Delivery Systems Patrick F. Kiser 539
Pulmonary Technologies
Pulmonary Delivery of Drugs by Inhalation Paul B. Myrdal B. Steven Angersbach 553
AERx Pulmonary Drug Delivery Systems David C. Cipolla Eric Johansson 563
Formulation Challenges of Powders for the Delivery of Small Molecular Weight Molecules as Aerosols Anthony J. Hickey Heidi M. Mansour 573
Adaptive Aerosol Delivery (AAD) Technology Kurt Nikander John Denyer 603
Nebulizer Technologies Martin Knoch Warren Finlay 613
Formulation Challenges: Protein Powders for Inhalation Hak-Kim Chan 623
The Respimat, a New Soft Mist Inhaler for Delivering Drugs to the Lungs Herbert Wachtel Achim Moser 637
Pressurized Metered Dose Inhalation Technology Ian C. Ashurst 647
Dry Powder Inhalation Systems from Nektar Therapeutics Andrew R. Clark Jeffry G. Weers 659
Technosphere/Insulin: Mimicking Endogenous Insulin Release Andrea Leone-Bay Marshall Grant 673
Index 681
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| $118.00 | Digital |
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Benjamin King
reviewed Modified Release Drug Delivery Technology, Vol. 2 on July 30, 2018
Modified Release Drug Delivery Technology
This is now one of my new favorite one volume histories of medicine. Even though it concentrates on the development of technology in medicine, and the author's underlying concern from the beginning is that physicians have sacrificed much of their personal relationship with the patient by adopting technology, it is a great and detailed discussion of auscultation, microscopy, the ophthalmoscope, the EKG, the roentgenogram, clinical chemistry and more. All histories must mention RTH Laennec, relate a tired discovery story, leave the reader to assume that the technology was adopted immediately and without complaint and then move on to the next item on the list, but Professor Reiser discusses the environment that the technology developed in, what the known probable sources were, who disliked or refused to use the new technology and why, and how and when it came to be used in common practice. All fascinating stuff; real history. This book was published in 1978 so its discussion of computers is dated in some ways, but in its essence nothing is really lost. As a personal complaint only, I think the book would be strengthened by more mention of the deleterious effects of the philosophy of mass automated screening of normal people - the false positives, the uncertain value to the patient of finding a true positive that might have had no effect on their life, whether a test is useful when it's clear that nothing can be done with the result, and what is sacrificed to pay for it all.
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Modified Release Drug Delivery Technology, Vol. 2, This two volume Second Edition describes the anatomical, physiological, pharmaceutical, and technological aspects of delivery routes, found in areas like:
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