Immunology at a Glance Book

Further reading 7

Immunity

1 The scope of immunology 8

2 Innate and adaptive immune mechanisms 10

3 Recognition and receptors: the keys to immunity 12

4 Evolution of immune mechanisms 14

5 Cells involved in immunity: the haematopoietic system 16

Innate immunity

6 Receptors of the innate immune system 18

7 Complement 20

8 Acute inflammation 22

9 Phagocytic cells and the reticuloendothelial system 24

10 Phagocytosis 26

Adaptive immunity

i The molecular basis

11 Evolution of recognition molecules: the immunoglobulin superfamily 28

12 The major histocompatibility complex 30

13 The T-cell receptor 32

14 Antibody diversification and synthesis 34

15 Antibody structure and function 36

ii The cellular basis

16 Lymphocytes 38

17 Primary lymphoid organs and lymphopoiesis 40

18 Secondary lymphoid organs and lymphocyte traffic 42

iii The adaptive immune response

19 Antigen processing and presentation 44

20 The antibody response 46

21 Antigen-antibody interaction and immune complexes 48

22 Cell-mediated immune responses 50

iv Regulation

23 Tolerance 52

24 Idiotypes, anti-idiotypes and networks 54

25 The cytokine network 56

26 Immunity, hormones and the brain 58

Potentially useful immunity

27 Antimicrobial immunity: a general scheme 60

28 Immunity to viruses 62

29 Immunity to bacteria 64

30 Immunity to fungi and ectoparasites 66

31 Immunity to protozoa 68

32 Immunity to worms 70

33 Immunity to tumours 72

Undesirable effects of immunity

34 Harmful immunity: a general scheme 74

35 Allergy and anaphylaxis 76

36 Immune complexes, complement and disease 78

37 Chronic and cell-mediated inflammation80

38 Autoimmunity 82

39 Transplant rejection 84

Altered immunity

40 Immunosuppression 86

41 Immunodeficiency 88

42 HIV and AIDS 90

43 Immunostimulation and vaccination 92

Immunity in health and disease

44 Immunity and clinical medicine 94

45 Investigating immunity 96

46 Into the future: immunology in the age of genomics 98

Self-assessment

Self-assessment questions 101

Answers 102

App. I Comparative sizes and molecular weights 103

App. II Landmarks in the history of immunology and some unsolved problems 104

App. III CD classification 105

Index 107