Genetic instability in cancer Book

	Introduction	1
	DNA Synthesis Errors, Mutators and Cancer	3
	DNA Polymerase [zeta] and the Control of DNA Damage Induced Mutagenesis in Eukaryotes	21
	Patterns of Mutation in Cancer Cells	33
	Mismatch Repair and Cancer	47
	Genomic Instability and Tolerance to Alkylating Agents	69
	The Relationship of DNA Methylation to Cancer	87
	Neoplastic Transformation: The Contrasting Stability of Human and Mouse Cells	103
	Damage Inducible Mutagenesis: Recent Insights into the Activities of the Umu Family of Mutagenesis Proteins	117
	The Relevance of Bacterial Mutators to Understanding Human Cancer	141
	Mutation in Resting Cells: The Role of Endogenous DNA Damage	155
	TP53 Tumour Suppressor Gene: Clues to Molecular Carcinogenesis and Cancer Therapy	169
	Telomere Maintenance in Tumour Cells	197
	Regulation of Genomic Instability in Preneoplastic Cells	217
	Chromosome Abnormalities in Leukaemia: The 11q23 Paradigm	225
	Clonal Chromosome Abnormalities in Neoplastic Cells: Evidence of Genetic Instability?	247
	DNA Damage Detection by DNA Dependent Protein Kinase and Related Enzymes	261
	Mammalian X Ray Sensitive Mutants: A Tool for the Elucidation of the Cellular Response to Ionizing Radiation	281
	Mechanism of V(D)J Recombination	295
	Transrearrangements as Biomarkers for Risk of Lymphoid Malignancy	311
	Many Mutations in Cancers	329
	Biographical Notes	343
	Index	347