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Preface | v | |
Foreword | vii | |
Contributors | xv | |
Part I | Cutaneous Carcinogenesis | 1 |
1. | History of Cutaneous Carcinogenesis | 2 |
2. | Multistage Mouse Model of Skin Carcinogenesis and Cell Cycle Regulation | 8 |
3. | Molecular Model of Cancer Development | 19 |
4. | Development of Metastases | 30 |
5. | Immune Surveillance Mechanisms | 39 |
6. | Skin Cancer in the Immunosuppressed Host | 51 |
7. | Differentiation Pathways | 61 |
8. | Cytokines and Growth Factors | 73 |
9. | Retinoids | 87 |
10. | The Role of Aging | 92 |
11. | Tumor-Stroma Interactions | 98 |
12. | Tumor Dormancy | 105 |
13. | DNA Damage and Repair | 110 |
14. | Mechanisms of Ultraviolet Radiation: Carcinogenesis and Immune Suppression | 115 |
15. | Epidemiology of Ultraviolet Radiation | 121 |
16. | The Ozone Layer | 129 |
17. | Ionizing Radiation | 134 |
18. | Chemicals | 141 |
19. | Viruses | 148 |
20. | Genetic Syndromes Predisposing to Skin Cancer Development | 158 |
21. | The Public Health Approach to Prevention of Skin Cancer | 169 |
22. | Chemoprevention of Skin Cancer | 175 |
Part II | Melanoma | 179 |
23. | History of Melanoma | 180 |
24. | Molecular Biology | 183 |
25. | Cell Structure and Function | 200 |
26. | Cellular Immunobiology | 211 |
27. | Biologic Factors | 218 |
28. | Precursor Melanocytic Lesions | 224 |
29. | Environmental and Host Risk Factors | 235 |
30. | Pregnancy and Estrogen | 243 |
31. | Follow-up Evaluation of Patients at Risk | 250 |
32. | Clinical Presentation | 253 |
33. | Histology | 262 |
34. | Factors Predictive of Metastasis and Outcome | 278 |
35. | Clinical Presentation and Diagnosis of Metastasis | 292 |
36. | Therapy of Melanoma In-situ (Lentigo Maligna) | 297 |
37. | Surgical Treatment of Stage I and II Disease (Excision, Lymphadenectomy, Limb Perfusion) | 303 |
38. | Radiation Therapy of Stage I and II Disease | 316 |
39. | Adjuvant Therapy of Stage I and II Disease | 323 |
40. | Therapy of Stage III and IV Disease | 331 |
41. | New Horizons and Research Techniques | 342 |
Part III | Squamous Cell Carcinoma | 349 |
42. | History of Squamous Cell Carcinoma | 350 |
43. | Molecular Biology | 353 |
44. | Cell Structure and Function | 361 |
45. | Cellular Immunobiology | 373 |
46. | Effects of Biological Factors | 379 |
47. | Risk Factors | 382 |
Color Plates Section | 391 | |
48. | Predisposing Genetic Syndromes and Clinical Settings | 457 |
49. | Clinical Presentation | 468 |
50. | Histology | 481 |
51. | Features Associated with Recurrence | 494 |
52. | Features Associated with Metastasis | 500 |
53. | Surgical Management of Local Disease | 506 |
54. | Cryosurgery | 518 |
55. | Radiation Therapy | 526 |
56. | Lasers and Photodynamic Therapy | 534 |
57. | Biologic Response Modifiers | 542 |
58. | Topical Chemotherapy | 547 |
59. | Surgery and Radiation Therapy for Advanced Disease | 553 |
60. | Chemotherapy and Biologic Response Modifiers for Advanced Disease | 558 |
61. | Follow-up and Prevention | 565 |
62. | Research Techniques and New Horizons | 571 |
Part IV | Basal Cell Carcinoma | 577 |
63. | History of Basal Cell Carcinoma | 578 |
64. | Pathogenesis | 581 |
65. | Molecular Genetics | 586 |
66. | Cell Structure and Function | 592 |
67. | Cellular Immunobiology | 599 |
68. | Biologic Factors | 604 |
69. | Aggressive versus Nonaggressive Subtypes | 609 |
70. | Risk Factors | 614 |
71. | Predisposing Genetic Syndromes and Clinical Settings | 619 |
72. | Clinical Presentation | 625 |
73. | Histology | 633 |
74. | Features Associated with Recurrence | 646 |
75. | Features Associated with Metastasis | 657 |
76. | Surgical Management of Local Disease | 664 |
77. | Cryosurgery | 672 |
78. | Radiation Therapy of Local Disease | 676 |
79. | Lasers and Photodynamic Therapy | 678 |
80. | Biologic Response Modifiers | 681 |
81. | Topical Chemotherapy | 687 |
82. | Adjuvant Therapy of Local Disease | 691 |
83. | Follow-up and Prevention | 695 |
84. | Regional and Distant Metastatic Disease | 699 |
85. | Research Techniques and New Horizons | 702 |
Part V | Other Cutaneous Tumors | 709 |
86. | Merkel Cell Carcinoma | 710 |
87. | Microcystic Adnexal Carcinoma | 722 |
88. | Primary Cutaneous Adenoid Cystic Carcinoma | 729 |
89. | Malignant Eccrine Spiradenoma | 734 |
90. | Malignant Clear Cell Hidradenoma | 738 |
91. | Malignant Chondroid Syringoma | 745 |
92. | Eccrine Porocarcinoma | 752 |
93. | Eccrine Mucinous Carcinoma | 758 |
94. | Malignant Cylindroma | 763 |
95. | Malignant Hidradenoma Papilliferum | 769 |
96. | Apocrine Carcinoma | 772 |
97. | Paget's Disease of the Nipple | 781 |
98. | Extramammary Paget's Disease | 789 |
99. | Malignant Ceruminoma | 796 |
100. | Sebaceous Gland Carcinoma | 800 |
101. | Pilomatrix Carcinoma | 811 |
102. | Overview of Soft-Tissue Sarcomas | 816 |
103. | Dermatofibrosarcoma Protuberans | 822 |
104. | Fibrosarcoma | 832 |
105. | Atypical Fibroxanthoma | 835 |
106. | Malignant Fibrous Histiocytoma | 844 |
107. | Liposarcoma | 852 |
108. | Angiosarcoma | 861 |
109. | Kaposi's Sarcoma | 873 |
110. | Hemangiopericytoma | 887 |
111. | Leiomyosarcoma | 893 |
112. | Cutaneous Rhabdomyosarcoma | 897 |
113. | Malignant Peripheral Nerve Sheath Tumor | 902 |
114. | Malignant Granular Cell Tumor | 907 |
115. | Epithelioid Sarcoma | 915 |
116. | Cutaneous T-Cell Lymphoma | 921 |
117. | Cutaneous B-Cell Lymphomas | 954 |
118. | Cancers Metastatic to the Skin | 964 |
Index | 973 |
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Add Cutaneous Oncology, Skin cancer is becoming a complicated disease to diagnose and treat with such an increasing number of causes. Cutaneous Oncology is the only comprehensive reference to look at all types of skin cancer, however rare or common, and the causes of each. It ad, Cutaneous Oncology to the inventory that you are selling on WonderClubX
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Add Cutaneous Oncology, Skin cancer is becoming a complicated disease to diagnose and treat with such an increasing number of causes. Cutaneous Oncology is the only comprehensive reference to look at all types of skin cancer, however rare or common, and the causes of each. It ad, Cutaneous Oncology to your collection on WonderClub |