Dermatologic, Cosmeceutic, and Cosmetic Development: Therapeutic and Novel Approaches Book

Preface     iii
Contributors     viii
Introduction
Skin Structure, Pharmaceuticals, Cosmetics, and the Efficacy of Topically Applied Agents   Michael S. Roberts   Kenneth A. Walters     1
Skin Disorders and Therapies
Drugs Used for Skin Diseases   Neil Kitson     11
Treatment of Dermatitis   Chris Anderson     21
Evolution of Cosmeceuticals and Their Application to Skin Disorders, Including Aging and Blemishes   Des Fernandes     45
Biology of Skin Pigmentation and Cosmetic Skin Color Control   Chong Jin Loy   Raman Govindarajan     61
Evidence-Based Cosmeceutical Therapy   Maria Miteva   Joachim W. Fluhr     97
Specific Factors Affecting Targeting and Efficacy
Skin Hydration-A Key Determinant in Topical Absorption   Michael S. Roberts   Joke Bouwstra   Fabrice Pirot   Francoise Falson     115
Epidemiology of Skin Barrier Function: Host and Environmental Factors   Greg G. Hillebrand   R. Randall Wickett     129
Permeability Through Diseased and Damaged Skin   Daniel A. W. Bucks     157
Targeting the Pilosebaceous Gland   Guang Wei Lu   Susan Ciotti   Satyanarayana Valiveti   JeffreyE. Grice   Sheree E. Cross     169
Drug Penetration Enhancement Through Human Nail and Skin   Thomas C. K. Chan   Kenneth A. Walters   Xiaoying Hui   Howard I. Maibach     189
Topical Pharmaceuticals, Formulations, and Indications
Getting the Dose Right in Dermatological Therapy   Adrian F. Davis     197
Drugs for Pain and Inflammation   Michael W. Whitehouse   Mantu Sarkar   Michael S. Roberts     215
Novel Topically Active Antimicrobial/Anti-inflammatory Compounds for Acne   Joseph A. Dunn   Robert A. Coburn   Richard T. Evans   Robert J. Genco   Kenneth A. Walters     243
Codrugs: Potential Therapies for Dermatological Diseases   Tadeusz Cynkowski   Grazyna Cynkowska   Kenneth A. Walters     255
Topical Therapeutic Agents Used in Wound Care   Sheree E. Cross     267
Established and Emerging Oral Antifungals in Dermatology   Gerald E. Pierard   Claudine Pierard-Franchimont   Valerie Vroome   Jorge Arrese   Pascale Quatresooz   Marcel Borgers   Geert Cauwenbergh     283
Hydroxy Acids and Retinoids in Cosmetic Products   Robert L. Bronaugh     297
Topical Cosmeceuticals, Formulations, and Indications
Natural Ingredients Used in Cosmeceuticals   Anthony C. Dweck     303
Influence of Formulation Design on the Clinical Performance of Topically Applied Formulations   Johann W. Wiechers     325
Dry Skin and Moisturizers   Anthony Vincent Rawlings   Paul John Matts     339
Antioxidants in the Skin: Dermatological and Cosmeceutical Aspects   Maxim Darvin   Juergen Lademann     373
Absorption and Evaporation of Volatile Compounds Applied to Skin   Gerald B. Kasting   Matthew A. Miller   Johannes M. Nitsche     385
Efficacy, Absorption, and Safety of Essential Oils   Ulrich F. Schafer   Jurgen Schneele   Sonja Schmitt   Jurgen Reichling     401
Sunscreens: Efficacy, Skin Penetration, and Toxicological Aspects   Heather A. E. Benson     419
Safety Considerations
Efficacy and Safety of Tea Tree and Other Oils   Christine F. Carson   Kate A. Hammer   Jesper B. Nielsen     437
Safety Assessments Based on Exposure, Skin Permeation and Toxicity Considerations   William E. Dressler   Kenneth A. Walters     453
Skin Assessment
Noninvasive Evaluation of Skin in the Cosmetic Industry   Carlos Galzote    Michael Suero   Raman Govindarajan     467
Application of In Vivo Scanning Microscopy for Skin Analysis in Dermatology and Cosmetology   Lars E. Meyer   Juergen Lademann     487
Improving Therapeutic Outcomes Using Chemical Techniques
Chemical Penetration Enhancement: Possibilities and Problems   Adrian C. Williams   Kenneth A. Walters     497
Multicomponent Formulations of Chemical Penetration Enhancers   Pankaj Karande   Amit Jain   Samir Mitragotri     505
Improving Therapeutic Outcomes Using Physical Techniques
Iontophoresis   Narayanasamy Kanikkannan   Michael Bonner   Jagdish Singh   Michael S. Roberts     517
DNA Transfer in the Skin   Gaelle Vandermeulen   Lievin Daugimont   Veronique Preat     537
Pressure Waves for Transdermal Drug Delivery   Apostolos G. Doukas   Sumit Paliwal   Samir Mitragotri     557
Microneedle Arrays as Transcutaneous Delivery Devices   James Birchall   Keith R. Brain     577
Needle-Free Ballistic Delivery of Powdered Immunotherapeutics to the Skin Using Supersonic Gas Flow   Mark A. F. Kendall     591