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Book Categories |
Preface | ||
Introduction | ||
Contributors | ||
1 | The Evolution of In Vitro Toxicology in the Pharmaceutical Industry | 1 |
2 | Relating In Vitro to In Vivo Exposures with Physiologically Based Tissue Dosimetry and Tissue Response Models | 9 |
3 | The Use of Theoretical Descriptors in Quantitative Structure-Activity Relationships | 27 |
4 | Structure-Activity Predictions as Alternatives to Animal Tests | 33 |
5 | The Aquatic Toxicology of Isopropylamine: Comparison of Experimentally Derived Values with Structure-Activity Predictions | 37 |
6 | Structure-Activity Relationships and the Validation of In Vitro Toxicology Tests | 47 |
7 | Applications of Liver and Kidney Cell Systems That Can Reduce Animal Usage | 57 |
8 | In Vitro Methods for Hepatotoxic Assessment of Halogenated Fatty Acids | 69 |
9 | Tissue Slices as an In Vitro Model for Studying Heart, Liver, and Kidney Toxicity | 83 |
10 | Potential for Interspecies Extrapolation of Macrophage Chemiluminescence Data from Immunotoxicology Studies | 91 |
11 | An In Vitro System for the Evaluation of Cyanide Ion Binding By Potential Candidate Antidotes | 99 |
12 | Munitions Cytotoxicities In Vitro | 103 |
13 | Neuroblastoma-Glioma Cells as a System for Studying Drug Neurotoxicity | 109 |
14 | In Vitro Assays for Muscle Irritation | 121 |
15 | General Overview of In Vitro and Other Alternatives to Skin Toxicity Evaluation | 131 |
16 | In Vitro Dermal Toxicity Assays: Validation with Human Data | 145 |
17 | Skin Penetration and Allergic Contact Dermatitis: Historical Perspective | 153 |
18 | Toward a Predictive Model for Allergic Contact Dermatitis | 159 |
19 | A Three-Dimensional Human Skin Model for Toxicity Testing | 167 |
20 | The SOLATEX-PI System: An In Vitro Method to Predict Photoirritation | 175 |
21 | Feasibility of Fluorescence Assays in Human Skin Equivalents with the CytoFluor 2300 | 191 |
22 | Ocular Testing: Historical Perspectives | 199 |
23 | Overview of In Vitro Ocular Irritation Test Systems and an Evaluation of Their Status | 203 |
24 | The Role of In Vitro Tests in Assessing the Safety of Cosmetics and Consumer Products | 211 |
25 | In Vitro and Other Alternatives in Inhalation Toxicology: Monitoring Biological Markers of Cellular and Biochemical Response | 221 |
26 | Alternatives to In Vivo Toxicological Testing of Rodent Airway Epithelia | 233 |
27 | Understanding Mechanisms of Carcinogenesis Using Rat Tracheal Epithelial Cells In Vitro | 241 |
28 | Development of a Short-Term Bioassay to Assess Pulmonary Toxicity of Inhaled Fibers | 249 |
29 | In Vitro Toxicity of Refractory Ceramic Fibers to Chinese Hamster Ovary Cells in Culture | 259 |
30 | Effects of Phosgene and Perfluoroisobutylene on Permeability of Pulmonary Endothelial Cells in Culture | 271 |
31 | In Vitro and Other Alternatives in Cardiovascular Research | 279 |
32 | Alternative Tests for Developmental Toxicity | 287 |
33 | Frog Embryo Teratogenesis Assay-Xenopus: A Nonmammalian Method for Developmental Toxicity Assessment | 297 |
34 | Earthworms as Substitutes for Rodents in Metal Toxicity | 315 |
35 | The Development and Validation of the Miniature Swine, Mouse, and Rabbit Models as Alternatives to the Use of the Dog in Drug Testing | 321 |
36 | Regulatory Requirements for Validation of In Vitro Alternative Tests | 327 |
37 | Consumer Safety, Harmonization of Test Methods and Classification Systems, and Validation of Alternatives | 331 |
38 | Epilogue | 335 |
Index | 339 |
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