Recombinant DNA Vaccines: Rationale and Strategy Book

	Preface
	Contributors
	Introduction
Pt. 1	Rationale
1	The Rationale for rDNA Vaccines	1
2	Modern Approaches to the Development of Attenuated Virus Strains	19
3	Development of Nontoxic Immunogenic Analogs of Toxins for Vaccines with Emphasis on Pertussis Toxin	49
4	Bacterial Virulence as Strategies to Develop Vaccines	73
5	Phase and Antigenic Variation of Bacterial Colonization Factors in the Development of Recombinant Vaccines	89
6	Antigenic Variation in Parasitic Protozoa	115
7	Strategies to Achieve Mucosal Immunity	147
Pt. 2	Strategy
8	Cloning Strategies in Prokaryotes	169
9	The Utility of Fusion Proteins in the Development of Vaccines	199
10	Vaccinia Virus as a Cloning and Delivery System for Vaccines	223
11	Baculovirus Expression Vectors	265
12	Use of Attenuated Bacteria as Live Oral Vaccine Vectors	293
13	Minicells as Specialized Vaccines and Vaccine Carriers	323
14	Rationale for the Design of Anti-Idiotypic Antibody Vaccines	335
15	The Iscom--An Approach to Subunit Vaccines	369
16	Safety of Recombinant Vaccines	387
	Index	401