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Foreword | iii | |
Preface | v | |
Contributors | xi | |
History of Parkinson' Disease Therapy | ||
1. | History of the Medical Therapy of Parkinson' Disease | 1 |
2. | History of Surgery for Parkinson's Disease | 21 |
Assessment of Signs and Symptoms of Parkinson's Disease | ||
3. | Clinical Assessments | 37 |
4. | Magnetic Resonance Imaging and Positron Emission Tomography Investigations | 53 |
Levodopa Therapy | ||
5. | Is Levodopa Toxic? | 71 |
6. | Levodopa Therapy | 81 |
7. | Levodopa Infusion | 93 |
Dopamine Agonists | ||
8. | Bromocriptine | 105 |
9. | Pergolide | 115 |
10. | Pramipexole | 131 |
11. | Ropinirole | 153 |
12. | Cabergoline | 163 |
13. | Apomorphine and Rotigotine | 177 |
COMT Inhibitors | ||
14. | Tolcapone | 187 |
15. | Entacapone | 203 |
Other Antiparkinsonian Medications | ||
16. | Anticholinergics | 213 |
17. | Selegiline | 223 |
18. | Amantadine | 233 |
Ablative Surgeries | ||
19. | Thalamotomy | 247 |
20. | Pallidotomy | 267 |
21. | Subthalamotomy | 279 |
Deep Brain Stimulation | ||
22. | Thalamic Deep Brain Stimulation | 293 |
23. | Globus Pallidal Deep Brain Stimulation | 309 |
24. | Subthalamic Nucleus Deep Brain Stimulation | 321 |
Other Treatment Options | ||
25. | Cell Transplantation | 343 |
26. | Electroconvulsive Therapy | 353 |
27. | Functional Radiosurgery in Movement Disorders | 359 |
28. | Transcranial Magnetic Stimulation | 367 |
Therapy for Nonmotor Symptoms | ||
29. | Autonomic Nervous System Disturbances | 377 |
30. | Sleep Problems | 389 |
31. | Psychosis and Dementia | 399 |
32. | Anxiety and Depression | 423 |
Nonmedical Management | ||
33. | Diet and Nutrition | 447 |
34. | Speech, Voice, and Swallowing Disorders | 461 |
35. | Physical and Occupational Therapy | 481 |
Investigational Therapies | ||
36. | New and Experimental Drug Treatments | 491 |
37. | Mitochondrial Dysfunction and Therapies | 507 |
38. | Trophic Factors: Potential Therapies | 517 |
39. | Neural Stem Cell Therapy | 529 |
Index | 553 |
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