Safety and Efficacy of Non-Prescription (OTC) Analgesics and NSAIDs Book

	List of Contributors, Co-Authors and Participants
	Preface
1	Current status of issues concerning the safety of over-the-counter analgesics and nonsteroidal anti-inflammatory drugs	1
2	Review of published clinical trial data on the adverse reactions from ibuprofen and paracetamol/acetaminophen at OTC dosages	11
3	Adverse drug reactions in the gastrointestinal system attributed to ibuprofen	19
4	The epidemiology of non-gastrointestinal adverse reactions from OTC analgesics	47
5	Renal safety of ibuprofen: pharmacokinetic aspects	73
6	Therapeutic considerations from pharmacokinetics and metabolism: ibuprofen and paracetamol	77
7	Acute human toxicity from NSAIDs and analgesics	93
8	Regulatory considerations concerning safety of OTC NSAIDs and analgesics	101
9	Evaluation of analgesic mechanisms and NSAIDs for acute pain using the oral surgery model	105
10	Multicentre study of the efficacy of ibuprofen compared with paracetamol in throat pain associated with tonsilitis	119
11	Ibuprofen plus caffeine in the treatment of migraine	123
	DEBATE - Safety and efficacy issues with OTC analgesics/NSAIDs	125
	Index	149