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Hypertension: A Companion to Brenner and Rector's the Kidney Book

Hypertension: A Companion to Brenner and Rector's the Kidney
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  • Hypertension: A Companion to Brenner and Rector's the Kidney
  • Written by author Suzanne Oparil
  • Published by Elsevier Health Sciences, October 1999
  • Presenting an excellent companion text to Brenner & Rector's THE KIDNEY. Provides a logical framework which can be utilized by practicing physicians to work up and manage their patients. Well-known authors discuss pertinent information from the main text,
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Section 1Background and Historical Aspects1
Chapter 1History of Clinical Hypertension: From 1827 to 19701
Chapter 2Epidemiology of Hypertension4
Section 2Pathophysiology21
Chapter 3Pathophysiology of Hypertension21
Chapter 4Genetics29
Chapter 5Sympathetic Nervous System in Acute and Chronic Blood Pressure Elevation42
Chapter 6Environmental and Psychosocial Stress in Hypertension Onset and Progression59
Chapter 7Renin and Prorenin70
Chapter 8Angiotensinogen: Physiology, Molecular Biology, and Relevance to Hypertension77
Chapter 9Angiotensin-Converting Enzyme: Basic Properties, Distribution, and Functional Role90
Chapter 10The AT[subscript 1] and AT[subscript 2] Angiotensin Receptors100
Chapter 11Metabolic Abnormalities in Hypertension110
Chapter 12Obesity-Related Hypertension as a Metabolic Disorder118
Chapter 13Remodeling of Resistance Vessels in Essential Hypertension125
Chapter 14Arterial Stiffness134
Chapter 15Endothelin in Hypertension152
Chapter 16Nitric Oxide in Hypertension158
Chapter 17Natriuretic Peptides165
Chapter 18Eicosanoids: Do They Matter?176
Chapter 19Calcitonin Gene-Related Peptide and Hypertension182
Chapter 20Kallikrein-Kinin Systems190
Diet--Nutrition
Chapter 21Diet--Micronutrients202
Chapter 22Obesity-Hypertension: Effects on the Cardiovascular and Renal Systems--The Therapeutic Approach206
Chapter 23Alcohol and Hypertension211
Section 3Target Organ Damage/Cardiovascular Complications221
Chapter 24Total Risk221
Chapter 25New Interpretations of Blood Pressure: The Importance of Pulse Pressure227
Chapter 26Coronary Atherosclerotic Sequelae of Hypertension235
Chapter 27Left Ventricular Hypertrophy, Congestive Heart Failure, and Coronary Flow Reserve Abnormalities in Hypertension244
Chapter 28Stroke and Hypertension277
Chapter 29Chronic Renal Insufficiency: Slowing Its Progression286
Section 4Diagnosis297
Chapter 30Initial Evaluation and Follow-Up297
Chapter 31Blood Pressure Measurement Issues306
Chapter 32White-Coat Hypertension314
Section 5Treatment--General Considerations323
Chapter 33Outcomes in Treating Hypertension323
Chapter 34Benefits of Treating Hypertension--Lessons From Clinical Trials331
Chapter 35Characteristics of Published, Ongoing, and Planned Outcome Trials in Hypertension341
Chapter 36The Antihypertensive and Lipid-Lowering to Prevent Heart Attack Trial360
Chapter 37The Losartan Intervention For Endpoint (LIFE) Reduction in Hypertension Study: Rationale, Design, and Characteristics of 9194 Patients With Left Ventricular Hypertrophy366
Chapter 38Changing Approaches to Diagnosis and Treatment of Hypertension371
Chapter 39Critical Assessment of Hypertension Guidelines375
Chapter 40Current Prescribing Practices383
Chapter 41Calcium Channel Blockers in the Treatment of Hypertension389
Chapter 42Mild Hypertension: An Important Frontier in Therapy of Hypertension398
Chapter 43Cost-Effectiveness in Treating Hypertension405
Chapter 44Nursing Clinics in the Management of Hypertension409
Chapter 45Community Outreach415
Chapter 46Medication Compliance for Antihypertensive Therapy419
Section 6Lifestyle Modification433
Chapter 47Diet--Micronutrients--Special Foods433
Chapter 48Diet--Calories460
Chapter 49Alcohol Consumption and the Management of Hypertension466
Chapter 50Exercise and Hypertension470
Section 7Pharmacological Treatment479
Chapter 51Initial Choices in the Treatment of Hypertension479
Chapter 52Dose-Response Relationships in Antihypertensive Treatment492
Chapter 53Low-Dose Fixed-Combination Antihypertensive Therapy497
Chapter 54Chronotherapeutics in the Treatment of Hypertension504
Section 8Comorbid Conditions--Special Considerations509
Chapter 55Comorbid Conditions509
Chapter 56Diabetes and Syndrome X: Focus on Reduction of Cardiovascular and Renal Events518
Chapter 57Renal Disease524
Chapter 58Hypertension in Patients on Renal Replacement Therapy531
Chapter 59Ischemic Heart Disease539
Chapter 60Hypertension in Women546
Chapter 61Hypertension in the Elderly551
Chapter 62Hypertension in Blacks558
Chapter 63Resistant Hypertension564
Chapter 64Orthostatic Hypotension572
Section 9Individual Drug Classes579
Chapter 65How Hypertensive Drugs Get Approved in the United States579
Chapter 66Diuretics584
Chapter 67[beta]-Adrenergic Blockers590
Chapter 68[alpha]-Adrenoceptor Blockers595
Chapter 69Angiotensin-Converting Enzyme Inhibitors599
Chapter 70Calcium Antagonists as Antihypertensives609
Chapter 71Angiotensin II Receptor Antagonists621
Chapter 72Other Adrenergic Inhibitors and the Direct-Acting Smooth Muscle Vasodilators637
New Classes
Chapter 73Endothelin Antagonists643
Chapter 74Renin Inhibitors646
Chapter 75Vasopeptide Inhibitors: A New Class of Cardiovascular Agents651
Section 10Secondary Hypertension657
Chapter 76Obstructive Sleep Apnea657
Chapter 77Renovascular Hypertension: Diagnosis and Treatment662
Chapter 78Adrenal Cortex674
Chapter 79Pheochromocytoma685
Chapter 80Hypertension in Pregnant Women688
Chapter 81Anesthesia and Hypertension702
Chapter 82Hypertensive Crisis715
AppendixDrug Tables719
Index723


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