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List of contributors viii
Principles and general methods 1
Introduction: Animal modeling - a precious tool for developing remedies to neurological diseases Turgut Tatlisumak Marc Fisher 3
Ethical issues, welfare laws, and regulations David Whittaker 6
Housing, feeding, and maintenance of rodents Robert W. Kemp 19
Identification of individual animals Turgut Tatlisumak Daniel Strbian 33
Analgesia, anesthesia, and postoperative care in laboratory animals Naoya Masutomi Makoto Shibutani 40
Euthanasia in small animals Turgut Tatlisumak 67
Various surgical procedures in rodents Rene Remie 75
Genetically engineered animals Carolina M. Maier Lilly Hsieh Pak H. Chan 114
Imaging in experimental neurology Marc Fisher Eng H. Lo Michael Lev 132
Safety in animal facilities Tarja Kohila 147
Behavioral testing in small-animal models: ischemic stroke Larry B. Goldstein 154
Methods for analyzing brain tissue Paivi Liesi 173
Targeting molecularconstructs of cellular function and injury through in vitro and in vivo experimental models Zhao Zhong Chong Faqi Li Kenneth Maiese 181
Neuroimmunology and immune-related neuropathologies Bao-Guo Xiao Hans Link 212
Animal models of sex differences in non-reproductive brain functions George T. Taylor Juergen Weiss Frank Zimmermann 239
The ependymal route for central nervous system gene therapy Erica Butti Gianvito Martino Roberto Furlan 257
Neural transplantation Stephen B. Dunnett Eduardo M. Torres Monte A. Gates Rosemary A. Fricker-Gates 269
Experimental models of major neurological diseases 309
Focal brain ischemia models in rodents Fuhai Li Turgut Tatlisumak 311
Rodent models of global cerebral ischemia Julia Kofler Richard J. Traystman 329
Rodent models of hemorrhagic stroke Fatima A. Sehba Joshua B. Bederson 345
In vivo models of traumatic brain injury Ronen R. Leker Shlomi Constantini 366
Experimental models for the study of CNS tumors Taichang Jang Lawrence Recht 375
Experimental models for demyelinating diseases Jason M. Link Richard E. Jones Halina Offner Arthur A. Vandenbark 393
Animal models of Parkinson's disease Anumantha G. Kanthasamy Siddharth Kaul 411
Animal models of epilepsy Ricardo M. Arida Alexandre V. Silva Margareth R. Priel Esper A. Cavalheiro 438
Experimental models of hydrocephalus Osaama H. Khan Marc R. del Bigio 457
Rodent models of experimental bacterial infections in the CNS Tammy Kielian 472
Experimental models of motor neuron disease/amyotrophic lateral sclerosis Ruth Danzeisen Birgit Schwalenstocker Albert C. Ludolph 487
Animal models for sleep disorders Seiji Nishino Nobuhiro Fujiki 504
Experimental models of muscle diseases Anu Suomalainen Katja E. Peltola Mjosund Anders Paetau Carina Wallgren-Pettersson 544
Index 562
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