Screening for Down's Syndrome Book

	List of contributors
1	Down's syndrome epidemiology and biochemical screening	1
2	Perception of risk	19
3	Risk estimation in Down's syndrome screening policy and practice	31
4	Screening by test combination: a statistical overview	47
5	Measurement of human chorionic gonadotrophin (hCG) as a screening test for Down's syndrome	73
6	The measurement of hCG subunits in screening for Down's syndrome	85
7	The measurement of free [beta]-hCG in screening for Down's syndrome	101
8	Multiple hCG-related molecules	119
9	Is the measurement of unconjugated oestriol of value in screening for Down's syndrome	141
10	Inhibin and CA 125 in Down's syndrome screening	163
11	Schwangerschafts protein 1 (SP1) and biochemical screening for Down's syndrome	171
12	Ultrasound and Down's syndrome	181
13	Prenatal diagnosis using fetal cells isolated from maternal blood	193
14	Rapid detection of chromosome aneuploidies in uncultured fetal cells using fluorescence in situ hybridisation	211
15	Organisation of screening programmes: a British experience	223
16	Organisation of screening programmes: the Californian experience	231
17	Organisation of screening programmes: the Dutch experience	237
18	Organisation of screening programmes: the French experience	245
19	The United Kingdom National External Quality Assessment Scheme for screening for Down's syndrome	255
20	Training obstetricians and midwives to offer serum screening for Down's syndrome	275
21	Biochemical screening for Down's syndrome in the first trimester	285
22	First trimester fetal nuchal translucency	295
23	Screening at 11 14 weeks of gestation: the role of established markers and PAPP-A	311
24	Mid-trimester biochemistry in prediction of third trimester complications	325
	Index	339