Process Development in Antibiotic Fermentations Book

Preface;

Part I. Background:

1. Introduction;
2. The microorganisms and methods of culture;
3. Microbial physiology;
4. Microbial biochemistry;
5. Subsidiary factors important in production fermentations;
6. Submerged culture conditions: the interaction between environment and genotype;

Part II. Process Development in the Laboratory:
7. Laboratory fermentation process development;
8. Assessment and understanding of experimental results;
9. Strain improvement;
10. Methods for laboratory process development;

Part III. Industrial Fermentation Plants and Pilot Plants:
11. Fermentation plants and pilot plants;
12. Process development in the fermentation plant;
13. Two plant problems: infection and variations in the level of production; Postscript; Bibliography; References; Index.