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Contributors | ||
Preface | ||
1 | A regulatory authority's opinion about surrogate endpoints | 3 |
2 | What to measure in dementia | 23 |
3 | Twenty-four-hour ambulatory arterial (blood) pressure measurement and the assessment of antihypertensive drug efficacy | 45 |
4 | Potential measurements in patients with osteoporosis | 63 |
5 | Are bronchial challenge studies indicators of antiasthmatic activity? | 77 |
6 | Measurements of blood rheology for the evaluation of pharmacological agents | 99 |
7 | Platelet function tests | 121 |
8 | Assessment of the effects of drugs on the peripheral vasculature | 135 |
9 | What are the valid measurements of drug efficacy in patients with intermittent claudication? | 151 |
10 | Bias and confounding in clinical studies | 175 |
11 | What does Good Clinical Practice have to say about clinical measurement? | 189 |
12 | Measurement of bioequivalence and its relevance to the clinical situation | 195 |
13 | The 'clinical trial' of the clinical trial | 205 |
14 | Patient compliance with prescribed drug regimens: overview of the past 30 years of research | 213 |
15 | Prediction of drug interactions: implications of recent advances in drug metabolism | 231 |
16 | What number of patients is necessary to establish drug safety? | 245 |
17 | Accuracy of adverse data from post-marketing studies and the influence on extension of licensed indications | 267 |
18 | Controlled clinical trials: contribution to drug safety | 281 |
19 | Predicting adverse drug reactions | 291 |
20 | Interactions in first-pass metabolism and variability in drug response | 301 |
Index | 315 |
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