Sold Out
Book Categories |
Preface xiii
Acknowledgments xvii
List of Contributors xix
Theoretical Introduction
Introduction 3
Bioprocesses 3
History of Biotechnology and Today's Situation 3
Future Perspectives 6
Modeling and Assessment in Process Development 7
Development of Bioprocesses 11
Types of Bioprocess and Bioproduct 11
Biocatalysts and Process Types 11
Raw Materials 17
Bioproducts 20
Bioreaction Stoichiometry, Thermodynamics, and Kinetics 23
Stoichiometry 23
Thermodynamics 28
Kinetics 29
Elements of Bioprocesses (Unit Operations and Unit Procedures) 32
Upstream Processing 33
Bioreactor 36
Downstream Processing 40
Waste Treatment, Reduction and Recycling 50
The Development Process 52
Introduction 52
Development Steps and Participants 53
Modeling and Simulation of Bioprocesses 61
Problem Structuring, Process Analysis, and Process Scheme 62
Model Boundariesand General Structure 62
Modeling Steps 63
Implementation and Simulation 66
Spreadsheet Model 66
Modeling using a Process Simulator 66
Uncertainty Analysis 71
Scenario Analysis 72
Sensitivity Analysis 73
Monte Carlo Simulation 75
Sustainability Assessment 81
Sustainability 81
Economic Assessment 82
Capital-Cost Estimation 83
Operating-Cost Estimation 88
Profitability Assessment 94
Environmental Assessment 95
Introduction 95
Structure of the Method 96
Impact Categories and Groups 99
Calculation of Environmental Factors 103
Calculation of Indices 105
Example Cleavage of Penicillin G 105
Assessing Social Aspects 107
Introduction 107
Indicators for Social Assessment 108
Interactions between the Different Sustainability Dimensions 112
Bioprocess Case Studies
Introduction to Case Studies 121
Citric Acid - Alternative Process using Starch 125
Introduction 125
Fermentation Model 125
Process Model 128
Inventory Analysis 130
Environmental Assessment 132
Economic Assessment 134
Conclusions 135
Pyruvic Acid - Fermentation with Alternative Downstream Processes 137
Introduction 137
Fermentation Model 137
Process Model 138
Bioreaction and Upstream 138
Downstream Processing 141
Inventory Analysis 142
Environmental Assessment 144
Economic Assessment 145
Conclusions 145
L-Lysine - Coupling of Bioreaction and Process Model Arnd Knoll Jochen Buechs 155
Introduction 155
Basic Strategy 156
Bioreaction Model 156
Process Model 159
Coupling of Bioreaction and Process Model 162
Assumptions 163
Results and Discussion 164
Riboflavin - Vitamin B[subscript 2] Wilfried Storhas Rolf Metz 169
Introduction 169
Biosynthesis and Fermentation 170
Production Process and Process Model 171
Upstream Processing 172
Fermentation 174
Downstream Processing 174
Inventory Analysis 174
Ecological Assessment 175
Economic Assessment 176
Discussion and Concluding Remarks 177
[Alpha]Cyclodextrin 181
Introduction 181
Reaction Model 182
Process Model 182
Solvent Process 182
Non-solvent Process 184
Inventory Analysis 185
Environmental Assessment 186
Economic Assessment 186
Conclusions 189
Penicillin V 193
Introduction 193
Modeling Base Case 193
Fermentation Model 193
Process Model 194
Inventory Analysis 196
Environmental Assessment 197
Economic Assessment 197
Monte Carlo Simulations 198
Objective Functions, Variables, and Probability Distributions 198
Results 201
Conclusions 206
Recombinant Human Serum Albumin M. Abdul Kholiq Elmar Heinzle 211
Introduction 211
Bioreaction Model 212
Stoichiometry 212
Multi-stage Fermentation and Feeding Plan 213
Total Broth Volume in Production Scale and Raw Material Consumption 214
Process Model 215
Bioreaction 215
Downstream Processing 215
Economic Assessment 218
Ecological Assessment 219
Conclusions 221
Recombinant Human Insulin Demetri Petrides 225
Introduction 225
Two-chain Method 226
Proinsulin Method 226
Market Analysis and Design Basis 226
Process Description 227
Inventory Analysis and Environmental Assessment 233
Production Scheduling 234
Economic Assessment 235
Throughput-Increase Options 237
Conclusions 238
Monoclonal Antibodies 241
Introduction 241
Process Model 241
Inventory Analysis 243
Economic Assessment 245
Environmental Assessment 246
Uncertainty Analysis 247
Scenarios 247
Sensitivity Analysis 248
Monte Carlo Simulations 249
Conclusions 255
[Alpha]-1-Antitrypsin from Transgenic Plant Cell Suspension Cultures Elizabeth Zapalac Karen McDonald 261
Introduction 261
Process Description 263
Model Description 263
Discussion 265
Conclusions 268
Plasmid DNA Sindelia S. Freitas Jose A. L. Santos D. Miguel F. Prazeres 271
Introduction 271
General 271
Case Introduction 272
Process Description 272
Model Description 275
Bioreaction Section 275
Downstream Sections 276
Inventory Analysis 277
Economic Assessment 278
Environmental Assessment 281
Discussion 282
Conclusions 283
Index 287
Login|Complaints|Blog|Games|Digital Media|Souls|Obituary|Contact Us|FAQ
CAN'T FIND WHAT YOU'RE LOOKING FOR? CLICK HERE!!! X
You must be logged in to add to WishlistX
This item is in your Wish ListX
This item is in your CollectionDevelopment of Sustainable Bioprocesses: Modeling and Assessment
X
This Item is in Your InventoryDevelopment of Sustainable Bioprocesses: Modeling and Assessment
X
You must be logged in to review the productsX
X
X
Add Development of Sustainable Bioprocesses: Modeling and Assessment, Bioprocess technology involves the combination of living matter (whole organism or enzymes ) with nutrients under laboratory conditions to make a desired product within the pharmaceutical, food, cosmetics, biotechnology, fine chemicals and bulk chemicals , Development of Sustainable Bioprocesses: Modeling and Assessment to the inventory that you are selling on WonderClubX
X
Add Development of Sustainable Bioprocesses: Modeling and Assessment, Bioprocess technology involves the combination of living matter (whole organism or enzymes ) with nutrients under laboratory conditions to make a desired product within the pharmaceutical, food, cosmetics, biotechnology, fine chemicals and bulk chemicals , Development of Sustainable Bioprocesses: Modeling and Assessment to your collection on WonderClub |