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Trends in Drug Research III, Pharmacochemistry Library, Vol. 32 Book

Trends in Drug Research III, Pharmacochemistry Library, Vol. 32
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  • Trends in Drug Research III, Pharmacochemistry Library, Vol. 32
  • Written by author Henk Van Der Goot
  • Published by Elsevier Health Sciences, March 2002
Buy Digital  USD$99.99

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Preface
Towards rational design of AMPA receptor ligands: an integrated medicinal, computational, biostructural and molecular pharmacological approach1
From heparin to synthetic antithrombotics. The pentasaccharide story and follow-up13
A new future for synthesis?21
Directed evolution of enantioselective enzymes as catalysts in the production of chiral pharmaceuticals27
At the interface of organic synthesis and biosynthesis39
What can structure tell us about function in the estrogen receptors?53
Molecular docking and dynamics simulations in the ligand binding domain of steroid hormone receptors57
Peroxisome proliferator-activated receptors and reverse endocrinology67
Biomolecular mass spectrometry related to drug research81
Chemical and biological diversity in drug discovery95
Muscarine acetylcholine receptor knockout mice: phenotypical analysis and clinical implications97
Changes in expression of the orphan G-protein coupled receptor GPR7 in human painful peripheral neuropathies115
Computational methods for the analysis of molecular diversity125
Enhancing drug discovery by acquisition of chemical diversity135
Chemical diversity as a driving force to design and put in practice synthetic strategies leading to combinatorial libraries for lead discovery and lead optimization147
Beyond G proteins: the role of accessory proteins in G protein-coupled receptor signalling161
Mechanisms of action of antipsychotic drugs: the role of inverse agonism at the D[subscript 2] dopamine receptor175
Agonist channeling of [alpha][subscript 2]-adrenoceptor function181
Antibacterials as wonder drugs and how their effectiveness is being compromised193
Pseudomonas aeruginosa quorum sensing: a target for antipathogenic drug discovery207
Discovery and development of new anti-bacterial drugs213
Discovery of small molecule insulin mimetics as potential novel antidiabetic agents227
Expression databases for pharmaceutical lead optimisation237
New developments in the pharmacology of cannabinoids249
Author index259
Subject index261


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