Ovarian Cancer: State of the Art and Future Directions in Translational Research Book

Pt. I Ovarian Cancer Detection and Pathogenesis

Potential and Limitations in Early Diagnosis of Ovarian Cancer Nicole Urban Urban, Nicole Charles Drescher Drescher, Charles 3

SMRP and HE4 as Biomarkers for Ovarian Carcinoma When Used Alone and in Combination with CA125 and/or Each Other Ingegerd Hellstrom Hellstrom, Ingegerd Karl Erik Hellstrom Hellstrom, Karl Erik 15

Classification of Ovarian Cancer: A Genomic Analysis Michael P. Stany Stany, Michael P. Tomas Bonorne Bonorne, Tomas Fred Wamunyokoli Wamunyokoli, Fred Kristen Zorn Zorn, Kristen Laurent Ozbun Ozbun, Laurent Dong-Choon Park Park, Dong-Choon Ke Hao Hao, Ke Jeff Boyd Boyd, Jeff Anil K. Sood Sood, Anil K. David M. Gershenson Gershenson, David M. Ross S. Berkowitz Berkowitz, Ross S. Samuel C. Mok Mok, Samuel C. Michael J. Birrer Birrer, Michael J. 23

Epigenetic Markers of Ovarian Cancer Caroline A. Barton Barton, Caroline A. Susan J. Clark Clark, Susan J. Neville F. Hacker Hacker, Neville F. Philippa M. O'Brien O'Brien, Philippa M. 35

Role of Genetic Polymorphisms in Ovarian Cancer Susceptibility: Development of an International Ovarian Cancer Association Consortium Andrew Berchuck Berchuck, Andrew Jaellen M. Schildkraut Schildkraut, Jaellen M. C. Leigh Pearce Pearce, C. Leigh Georgia Chenevix-Trench Chenevix-Trench, Georgia Paul D. Pharoah Pharoah, Paul D. 53

MicroRNA in Human Cancer: One Step Forward in Diagnosis and Treatment Lin Zhang Lin, Zhang Nuo Yang Nuo, Yang George Coukos Coukos, George 69

Ovarian Carcinogenesis: An Alternative Hypothesis Jurgen M. J. Piek Piek, Jurgen M. J. Paul J. van Diest van Diest, Paul J. Rene H. M. Verheijen Verheijen, Rene H. M. 79

BRCA1-Induced OvarianOncogenesis Louis Dubea Dubea, Louis 89

Role of p53 and Rb in Ovarian Cancer David C. Corney Corney, David C. Andrea Flesken-Nikitin Flesken-Nikitin, Andrea Jinhyang Choi Choi, Jinhyang Alexander Yu. Nikitin Nikitin, Alexander Yu. 99

Ovulatory Factor in Ovarian Carcinogenesis William J. Murdoch Murdoch, William J. 119

Pt. II Ovarian Cancer Therapeutics

Gynecologic Oncology Group (GOG.USA) Trials in Ovarian Cancer Robert F. Ozols Ozols, Robert F. 131

Intraperitoneal Chemotherapy for Ovarian Cancer Mark A. Morgan Morgan, Mark A. 145

Ovarian Cancer: Can We Reverse Drug Resistance? David S. P. Tan Tan, David S. P. Joo Ern Ang Ang, Joo Ern Stan B. Kaye Kaye, Stan B. 153

Syngeneic Mouse Model of Epithelial Ovarian Cancer: Effects of Nanoparticulate Paclitaxel, Nanotax Katherine F. Roby Roby, Katherine F. Fenghui Niu Niu, Fenghui Roger A. Rajewski Rajewski, Roger A. Charles Decedue Decedue, Charles Bala Subramaniam Subramaniam, Bala Paul F. Terranova Terranova, Paul F. 169

Individualized Molecular Medicine: Linking Functional Proteomics to Select Therapeutics Targeting the PI3K Pathway for Specific Patients Mandi M. Murph Murph, Mandi M. Debra L. Smith Smith, Debra L. Bryan Hennessy Hennessy, Bryan Yiling Lu Lu, Yiling Corwin Joy Joy, Corwin Kevin R. Coombes Coombes, Kevin R. Gordon B. Mills Mills, Gordon B. 183

Defective Apoptosis Underlies Chemoresistance in Ovarian Cancer Karen M. Hajra Hajra, Karen M. Lijun Tan Tan, Lijun J. Rebecca Liu Liu, J. Rebecca 197

Nanoparticle Delivery of Suicide DNA for Epithelial Ovarian Cancer Therapy Janel A. Sawicki Sawicki, Janel A. Daniel G. Anderson Anderson, Daniel G. Robert Langer Langer, Robert 209

Biological Therapy with Oncolytic Herpesvirus Fabian Benencia Benencia, Fabian George Coukos Coukos, George 221

Cancer Immunotherapy: Perspectives and Prospects Sonia A. Perez Perez, Sonia A. Michael Papamichail Papamichail, Michael 235

Regulatory T Cells: A New Frontier in Cancer Immunotherapy Brian G. Barnett Barnett, Brian G. Jens Ruter Ruter, Jens Ilona Kryczek Kryczek, Ilona Michael J. Brumlik Brumlik, Michael J. Pui Joan Cheng Cheng, Pui Joan Benjamin J. Daniel Daniel, Benjamin J. George Coukos Coukos, George Weiping Zou Zou, Weiping Tyler J. Curiel Curiel, Tyler J. 255

Inhibitory B7 Family Members in Human Ovarian Carcinoma Shuang Wei Shuang, Wei Tyler Curiel Curiel, Tyler George Coukos Coukos, George Rebecca Liu Liu, Rebecca Weiping Zou Zou, Weiping 261

Role of Vascular Leukocytes in Ovarian Cancer Neovascularization Klara Balint Balint, Klara Jose R. Conejo-Garcia Conejo-Garcia, Jose R. Ron Buckanovich Buckanovich, Ron George Coukos Coukos, George 273

Heparin-Binding Epidermal Growth Factor-Like Growth Factor as a New Target Molecule for Cancer Therapy Shingo Miyamoto Miyamoto, Shingo Hiroshi Yagi Yagi, Hiroshi Fusanori Yotsumoto Yotsumoto, Fusanori Tatsuhiko Kawarabayashi Kawarabayashi, Tatsuhiko Eisuke Mekada Mekada, Eisuke 281

Index 297