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Summary 1
1 Introduction 17
2 An Imperative for Change 33
3 Setting Priorities for Evidence Assessment 57
4 Systematic Reviews: The Central Link Between Evidence and Clinical Decision Making 81
5 Developing Trusted Clinical Practice Guidelines 121
6 Building a Foundation for Knowing What Works in Health Care 153
App. A Acronyms and Abbreviations 179
App. B Workshop Agendas and Questions to Panelists 181
App. C Template for Submissions of Topics to the Agency for Healthcare Research and Quality 193
App. D Standards for Reporting Meta-Analyses of Clinical Trials and Observational Studies: QUOROM and MOOSE 199
App. E Examples of ECRI Institute and Hayes, Inc., Quick Turnaround Reports 205
App. F Guideline Standards: The AGREE Instrument and COGS Checklist 231
App. G Committee Biographies 237
Index 247
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