Dietary Supplements: A Framework for Evaluating Safety Book

1	Introduction and background	19
2	Approaches used by others and existing safety frameworks	43
3	The framework	85
4	Categories of scientific evidence - human information and data	126
5	Categories of scientific evidence - animal data	156
6	Categories of scientific evidence - information about related substances	175
7	Categories of scientific evidence - in vitro data	217
8	Interactions	235
9	Vulnerable groups and prevalence of use	247
10	Scientific principles for integrating and evaluating the available data	253
11	Applying the framework : case studies using the prototype safety monographs	269
12	Factors influencing use of the safety framework	292
13	Findings and recommendations	297
App. A	Existing frameworks or systems for evaluating the safety of other substances	307
App. B	Scope of work and comments to initial July 2002 framework	316
App. C	Plant family information	322
App. D	Chaparral : prototype monograph summary	356
App. E	Glucosamine : prototype monograph summary	363
App. F	Melatonin : prototype monograph summary	367
App. G	Chromium picolinate : prototype monograph summary	372
App. H	Saw palmetto : prototype monograph summary	376
App. I	Shark cartilage : prototype monograph summary	380
App. J	Prototype focused monograph : review of liver-related risks for chaparral	385
App. K	Prototype focused monograph : review of antiandrogenic risks of saw palmetto ingestion by women	450
App. L	Acknowledgments	478
App. M	Biographical sketches of committee members	481