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Excitatory Amino Acid Receptors: Design of Agonists and Antagonists Book

Excitatory Amino Acid Receptors: Design of Agonists and Antagonists
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  • Excitatory Amino Acid Receptors: Design of Agonists and Antagonists
  • Written by author Povl Krogsgaard-Larsen, J. J. Hansen
  • Published by Taylor & Francis, Inc., 7/28/1992
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Authors

Preface 7
Abbreviations of names of compounds 9
1 Excitatory amino acids, excitotoxicity and neurodegenerative disorders 13
2 Excitatory amino acid receptors: multiplicity and ligand selectivity of receptor subtypes 34
3 Isolation and structural characterization of excitatory amino acid receptors 56
4 Electrophysiological techniques for the study of excitatory amino acids in mammalian neurons in slice preparations 86
5 Receptor autoradiography of excitatory amino acid receptors: basic and clinical aspects 101
6 NMDA receptors: heterogeneity and agonism 121
7 Sulphur-containing excitatory amino acids 162
8 Competitive NMDA receptor antagonists 183
9 Ligands for NMDA receptor modulatory sites 201
10 AMPA receptor agonists: structural, conformational and stereochemical aspects 216
11 Quinoxalinediones as AMPA receptor antagonists: mechanism and structure-activity studies 246
12 Kainic acid receptor agonists 261
13 Polyamine toxins as excitatory amino acid receptor ligands 292
14 L-AP4 receptor ligands 308
15 The quisqualate metabotropic receptor coupled to phospholipase C(Qp) 331
16 Therapeutic opportunities in modulators of excitatory amino acid-mediated neurotransmission 352
Index 376


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