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Contributors ix
Preface xi
Computer-Based Clinical Decision Support: Concepts and Origins 1
Definition, Scope, and Challenges Robert A. Greenes 3
A Brief History of Clinical Decision Support: Technical, Social, Cultural, Economic, and Governmental Perspectives Robert A. Greenes 31
Features of Computer-Based Clinical Decision Support Robert A. Greenes 79
Case Studies and Current Status 109
Regenstrief Medical Informatics: Experiences with Clinical Decision Support Systems Paul Biondich Burke Mamlin William Tierney Marc Overhage Clement McDonald 111
Patients, Doctors, and Information Technology: Clinical Decision Support at Brigham and Women's Hospital and Partners HealthCare David W. Bates Helen G. Lo 127
Case Studies in Clinical Decision Support: LDS Hospital Experience R. Scott Evans 143
Penetration and Availability of Clinical Decision Support in Commercial Systems Kent Gale Jason Hess 169
Lessons Learned Robert A. Greenes 195
Generation and Formulation of Knowledge 205
Human-Intensive Techniques Edward H. Shortliffe Vimla L. Patel 207
Generation of Knowledge for Clinical Decision Support: Statistical and Machine Learning Techniques Michael E. Matheny Lucila Ohno-Machado 227
Evidence-Based Medicine and Meta-Analysis: Getting More Out of the Literature Joseph Lau 249
Representing the Knowledge: Standardization Efforts 265
Decision Rules and Expressions Robert A. Jenders 267
Guidelines and Workflow Models Nor Peleg 281
Ontologies, Vocabularies, and Data Models Stanley M. Huff 307
Grouped Knowledge Elements Margarita Sordo Matvey B. Palchuk 325
Infobuttons and Point of Care Access to Knowledge James J. Cimino Guilherme Del Fiol 345
The Role of Standards: What We Can Expect and When Robert A. Greenes 373
Organizational, Business, and Social Challenges 383
Organizational and Cultural Change Considerations Joan S. Ash 385
Managing the Investment in Clinical Decision Support John Glaser Tonya Hongsermeier 403
Legal and Regulatory Issues Related to the Use of Clinical Software in Health Care Delivery Randolph A. Miller Sarah M. Miller 423
Knowledge Management Approaches 445
Knowledge Management Infrastructure: Evolution at Partners Healthcare System Tonya Hongsermeier Vipul Kashyap Margarita Sordo 447
The Clinical Knowledge Management Infrastructure of Intermountain Healthcare Roberto A. Rocha Richard L. Bradshaw Nathan C. Hulse Beatriz H. S. C. Rocha 469
Integration of Knowledge Resources into Applications to Enable Clinical Decision Support: Architectural Considerations Kensaku Kawamoto 503
The Road Ahead 539
A Proposed Strategy for Overcoming Inertia Robert A. Greenes 541
Index 571
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