Bone Cancer: Progression and Therapeutic Approaches Book

Section 1: Introduction

Genetic control, frequencies and epidemiology of bone cancers

The incidence and progression of metastatic bone lesions

Section 2: Bone microenvironment and bone cancer

Bone microenvironment and tumor growth

Osteoblast Differentiation and Cell Signalling

Osteoclast Differentiation and Function

Cytokines in bone remodeling and bone tumors

Proteases and bone tumors - therapeutic approaches

Section 3: Bone markers

Early bone metastasis

Bone remodeling markers and bone cancer

Proteomic of bone cancers

Genomic Alterations in Bone Tumors

Biology of bone tumors and new diagnostic tools

Gene profiling of osteosarcoma

Molecular pathology of osteosarcoma

Histopathology of prostate and breast metastases

Technical aspects: how do we best prepare bone samples for proper histological analysis?

Section 4: Myeloma, odontogenic tumors and bone metastases

Multiple myeloma bone diseases

Osteolytic lesions

Bone metastases of prostatic cancer

Bone metastases of breast cancer

Section 5: Primary bone tumors

Osteosarcoma and osteoblasts: diagnosis and therapy

Ewing sarcoma family of tumors: diagnosis and therapy

Non-surgical treatment of chondrosarcoma: diagnosis and therapy

Chondrosarcoma of bone: diagnosis and therapy

Osteoclast-rich lesions of bone: diagnosis and therapy

Section 6: Imaging of bone cancers

Interventional Radiologic Techniques

Imaging of bone metastases

Diagnosis of bone metastases

Section 7: Pain control in bone cancers

Pain control with radiotherapy

Mechanisms and management of bone cancer pain

Malignant skeletal pain

Section 8: New therapeutic advances of bone cancers

Primary bone tumors and novel therapeutic approaches

Cytokine gene therapy in bone remodeling

Bisphosphonates

Multi-targeted approach

RANKL and targeted therapy

Apoptosis and drug resistance